The effect of vitamin D supplementation on premenstrual syndrome(PMS)

Not Applicable

Conditions: premenstrual syndrome.

Registration Number: IRCT20180525039822N1

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 44

Inclusion Criteria

Age of 25-18 years
BMI in normal range
single
Serum vitamin D level is 30- 10 ng / ml
Having a regular menstrual cycle with intervals of 35 to 21 days
Not doing regular exercise
Students do not start or finish their studies in the semester

Exclusion Criteria

Acute and chronic diseases such as: cardiovascular, kidney, liver, diabetes, hypothyroidism, hyperthyroidism and asthma
Iron deficiency anemia (Anemia)
Depression and anxiety
Consumption of combined pills containing estrogen and progesterone
Take supplemental vitamin D in the last 3 months

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum level of interleukin 10 based on ELISA method. Timepoint: At the beginning of the study and after 4 months of intervention. Method of measurement: Blood sampling and serum level determination using ELISA kit.;Serum level of interleukin 12 based on ELISA method. Timepoint: At the beginning of the study and after 4 months of intervention. Method of measurement: Blood sampling and serum level determination using ELISA kit.;Serum level of total antioxidant capacity based on ELISA method. Timepoint: At the beginning of the study and after 4 months of intervention. Method of measurement: Blood sampling and serum level determination using ELISA kit.;Score of physical symptoms and mood syndrome in premenstrual syndrome in the symptom registration questionnaire. Timepoint: At the beginning of the study and after 4 months of intervention. Method of measurement: Premenstrual Signs Indexing Questionnaire (DSM-IV).

Secondary Outcome Measures