Diagnosis and Therapy of Vulnerable Atherosclerotic Plaque

Not Applicable

Completed

• Conditions: Carotid Atherosclerosis; Stroke; Type 2 Diabetes; Metabolic Syndrome
• Interventions: Drug: atorvastatin; Drug: rimonabant; Drug: rosiglitazone; Drug: metformin

• Registration Number: NCT00636766
• Lead Sponsor: Aristotle University Of Thessaloniki

Brief Summary

The aim of the present study is to examine the atherosclerotic plaque stability using in vivo and in vitro techniques and to investigate the influence of exercise, anti-diabetic, lipid-lowering and cannabinoids receptor antagonists on atherosclerotic plaque texture in patients with cardiovascular risk and animals prone to atherosclerosis.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-09
• Primary Completion: 2007-12
• Study First Submitted: 2008-03-11
• Study First Submitted QC: 2008-03-11
• Study First Posted: 2008-03-14
• Study Completion: 2009-01
• Status Verified: 2012-11
• Last Update Submitted: 2012-11-01
• Last Update Posted: 2012-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• Carotid atherosclerosis
• Femoral atherosclerosis
• Cardiovascular risk

Exclusion Criteria

• Heart failure
• Renal disease
• Liver disease
• Life-threatening diseases

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
1	atorvastatin	-
1	rimonabant	-
1	rosiglitazone	-
1	metformin	-

Primary Outcome Measures

Name	Time	Method
Ultrasound and immunohistochemical parameters of plaque stability; novel cardiovascular risk factors	3 years

Secondary Outcome Measures

Name	Time	Method
Long-term cardiovascular outcomes	3 years

Trial Locations

Locations (1)

General Hospital of Thessaloniki "Hippokratio"; 🇬🇷 Thessaloniki, Greece