NCT02803411
Active, not recruiting
Not Applicable
Progression of AtheRosclerotic PlAque DetermIned by Computed TomoGraphic Angiography Imaging(PARADIGM)
ConditionsCoronary Heart Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Coronary Heart Disease
- Sponsor
- Yonsei University
- Enrollment
- 2000
- Primary Endpoint
- Change in plaque volume and composition detected by follow up CCTA
- Status
- Active, not recruiting
- Last Updated
- 7 years ago
Overview
Brief Summary
To describe the natural history of the coronary atherosclerotic plaque development and progression over time by CCTA with demographic and laboratory data for refinement of risk stratification of patients referred for CCTA.
Detailed Description
All PARADIGM study patients underwent initial and follow-up CCTA based on order from their primary physician. Demographic data, targeted medical history, cardiovascular risk factors, and laboratory data was prospectively collected in electronic case report forms (eCRFs) at the time of the initial CCTA and at the time of follow-up CCTA.
Investigators
Hyuk-Jae Chang
Professor
Yonsei University
Eligibility Criteria
Inclusion Criteria
- •patients underwent two or more clinically indicated CCTA with 64-detector rows or greater for CAD evaluation
- •patients underwent at least 2 year interval between the baseline and follow-up CCTA
Exclusion Criteria
- •poor image quality of CCTA
Outcomes
Primary Outcomes
Change in plaque volume and composition detected by follow up CCTA
Time Frame: 2 years
Secondary Outcomes
- Myocardial infarction (yes or no)(2 years)
- Revascularization (yes or no)(2 years)
- Cardiac mortality (yes or no)(2 years)
- Unstable angina requiring hospitalization (yes or no)(2 years)
Similar Trials
Active, not recruiting
Not Applicable
Prediction of Atherosclerotic Plaque ProgressionCoronary Artery DiseaseNCT05424705Na Homolce Hospital40
Completed
Not Applicable
Investigation of the progression of atherosclerosis and atherosclerotic risk factor in patients with diabetesDiabetesJPRN-UMIN000014765Division of diabetes, Mitsui Memorial Hospital700
Active, not recruiting
Not Applicable
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging TechniqueCoronary ArteriosclerosisNCT00540761Massachusetts General Hospital320
Unknown
Not Applicable
Prediction of Progression of Coronary Artery Disease (CAD) Using Vascular Profiling of Shear Stress and Wall MorphologyCoronary AtherosclerosisAcute Coronary SyndromePercutaneous Coronary InterventionEndothelial Shear StressArterial RemodelingNCT01316159Brigham and Women's Hospital506
Not yet recruiting
Not Applicable
Investigation of atherosclerotic formation mechanisms associating diurnal variation of blood glucose in patients with lifestyle-related diseaselifestyle-related disease and healthy volunteerJPRN-UMIN000014404Gunma University Hospital100