Dose response of DHA and vitamin supplements during pregnancy and lactation to increase the breast milk DHA content to 0.7-1.0 g%.

Completed

Conditions: geen, namelijk doseringsonderzoek naar moedermelkconcentraties DHA en vitamine D na suppletie met DHA en vitamine D bij zwangere en lacterende vrouwen
gravidarum
pregnancy

Registration Number: NL-OMON41801

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 56

Inclusion Criteria

- apparently healthy women, during a non-complicated single pregnancy
- BMI between 18 and 25 kg/m2 before pregnancy
- good control of the Dutch language
- Willingly to stop taking multivitamins, folic acid, vitamin D and fish oil supplements if taken

Exclusion Criteria

- hyperemesis graviradrum
- vegetarian or vegan diet
- diabetes mellitus type I;criteria for individual ending of the study:
- premature birth (gestational age less than 37 weeks) en birth after 42 weeks
- complications mother
- pregnancy diabetes
- pre-eclampsia, placental insufficiency, intrauterine growth retardation

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary aim of the study is to find the dose of vitamin D during the<br /><br>pregnancy and lactation that leads to mean breast milk DHA contents of at least<br /><br>0,7g%.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The secundary aim of the study is to find the dose of vitamin D during the<br /><br>pregnancy and lactation that causes a breast milk vitamin D content of 35<br /><br>nmol/L.<br /><br><br /><br>Increasing breast milk of vitamin B1, vitamin B2, vitamin B12, magnesium,<br /><br>iodide and selenium to 0.48 nmol/L, 5.26 nmol/L, 310 pmol/L, 1,4 nmol/L, 0,8<br /><br>µmol/L and 16.3 nmol/L respectively.</p><br>