Obesity and Its Associated Co-morbidities in Children With Nephrotic Syndrome: A Cross-sectional Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 72
- 试验地点
- 1
- 主要终点
- 1. To determine the prevalence of obesity and overweight in children with nephrotic syndrome
研究概览
简要总结
Obesity in this population not only increases the risk for cardiovascular comorbidities such as hypertension and dyslipidaemia, but it may also influence the course of NS by contributing to more frequent relapses, reducing steroid responsiveness, and increasing the likelihood of progression to chronic kidney disease (CKD). (6)
Long-term corticosteroid therapy, commonly used in NS management, exacerbates these risks by impairing glucose metabolism, promoting hepatic gluconeogenesis. The co-existence of obesity, NS, and corticosteroid therapy thus creates a metabolic environment to the development of diabetes mellitus. (7)
Despite increasing awareness of the complex interplay between nephrotic syndrome, obesity, and diabetes mellitus in children, existing literature remains limited, with most studies focusing on adult populations or exploring these conditions in isolation. (8)
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 1.00 Year(s) 至 18.00 Year(s)（—）
- 性别
- All
入选标准
- •1-18year-old children with nephrotic syndrome.
排除标准
- •children with first episode of nephrotic syndrome
- •children with secondary causes of nephrotic syndrome.
结局指标
主要结局
1. To determine the prevalence of obesity and overweight in children with nephrotic syndrome
时间窗: 50weeks
2.To analyse short stature among nephrotic syndrome patients
时间窗: 50weeks
3.To estimate the prevalence of diabetes mellitus in these children
时间窗: 50weeks
次要结局
- 1.To analyse short stature among nephrotic syndrome patients(2.To estimate the prevalence of diabetes mellitus in these children)
研究者
PUTTARAJ MUDAGAL
Jawaharlal Nehru Medical College