Effect of Herring Oil Concentrate on LDL Cholesterol Concentration in Adults
- Conditions
- High Cholesterol
- Interventions
- Dietary Supplement: Herring oil concentrateDietary Supplement: Control
- Registration Number
- NCT06364163
- Lead Sponsor
- University of Bergen
- Brief Summary
High cholesterol concentration is a major risk factor for cardiovascular disease (CVD), and consumption of fish has been associated with a lower CVD risk in several studies. The beneficial health effects of consuming fish have traditionally been ascribed to the long-chain PUFA (LC-PUFA) EPA (C20:5n-3) and DHA (C22:6n-3), although consumption of fish oils or concentrates with high EPA and DHA contents does not affect the cholesterol concentration in humans and lowers the cholesterol concentration in rats and mice only when given in very high doses. Fish oils contain a plethora of fatty acids besides EPA and DHA, and in recent years, increased focus has been on the long-chain MUFA (LC-MUFA) cetoleic acid (C22:1n-11). Cetoleic acid is found in high amounts in oils from certain fish species such as herring, which has relatively low contents of both EPA and DHA. The investigators have recently summarised and meta-analysed the available literature that investigates the effects of diets containing fish oils or fish oil concentrates that have a high content of cetoleic acid but low or no content of EPA and DHA on cholesterol concentration in rodents, showing that cetoleic acid-rich fish oils and concentrates prevent high cholesterol concentration.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 80
- BMI over 27 kg/m2
- Stable body weight last 3 months
- Allergies towards fish, milk, egg, gluten
- Tobacco use (cigarettes or snus)
- Diseases affecting the heart, intestinal function, kidney function or insulin secretion
- Use of medications targeting cholesterol -or glucose metabolism, hypertension
- Use of dietary supplements
- Pregnant or breastfeeding
- Following a strict diet
- Had bariatric surgery
- Recent or planned surgical procedures
- High intake of fish/seafood
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Herring oil concentrate Herring oil concentrate Dietary supplement: herring oil concentrate in capsules, 4 g oil daily for 8 weeks Control oil Control Dietary supplement: control oil in capsules, 4 g oil daily for 8 weeks
- Primary Outcome Measures
Name Time Method Serum concentration of LDL-cholesterol 8 weeks LDL-cholesterol will be measured in fasting serum samples
- Secondary Outcome Measures
Name Time Method Serum concentration of glucose 8 weeks Glucose will be measured in serum sampled in fasting condition
Serum concentration of insulin 8 weeks Insulin will be measured in serum sampled in fasting condition
Urine concentrations of T cell immunoglobulin mucin-1 (TIM-1) 8 weeks T cell immunoglobulin mucin-1 (TIM-1) will be analysed in morning urine as a marker of kidney function
Fatty acid composition in leukocytes 8 weeks Leukocytes will be isolated from fasting serum before quantification of fatty acids
Serum concentration of HDL-cholesterol 8 weeks HDL-cholesterol will be measured in fasting serum samples
Serum concentration of total cholesterol 8 weeks Total cholesterol will be measured in fasting serum samples
Serum concentrations of amino acids metabolites 8 weeks Metabolites of amino acids will be measured in fasting serum samples
Urine concentrations of cystatin C 8 weeks Cystatin C will be analysed in morning urine as a marker of kidney function
Body composition 8 weeks Percent body fat will be measured using bioimpedance
Serum concentrations of apolipoproteins 8 weeks Lipoproteins will be measured in fasting serum samples
Serum concentration of one-carbon pathway metabolites 8 weeks Metabolites in the one-carbon pathway will be measured in fasting serum samples
Trial Locations
- Locations (1)
University of Bergen
🇳🇴Bergen, Norway