Assessment of Mediastinal Masses With Diffusion Weighted MR Imaging
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 试验地点
- 1
- 主要终点
- sensitivity and specificity of magnetic resonance imaging diffusion in mediastinal masses
研究概览
简要总结
Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy which is essential for treatment planning as well as for prognosis
详细描述
Differentiation between benign and malignant mediastinal tumors as well as characterization and grading of malignancy is essential for treatment planning as well as for prognosis .
MRI presents valuable diagnostic information in assessing the mediastinum. In addition, special applications have been developed over recent years diffusion-weighted magnetic resonance imaging is one such technique The advent of echo-planar imaging technique has rendered diffusion weighted imaging of the abdomen and thoracic cavity possible .
Quantitative assessment of the mediastinal mass is possible by calculation of apparent diffusion co-efficient value ,which is related to the proportion of extracellular and intracellular component.
The apparent diffusion co-efficient is inversely correlated with tissue cellularity. It is lower in viable tumor tissue with densely packed diffusion-hindering obstacles than in tissue with less densely packed obstacles such as tumor necrosis and benign tissue .
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Cross Sectional
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any age groups
- •diagnosis of mediastinal mass (by Multislice Computed Tomography).
排除标准
- •chemotherapy radiotherapy.
- •thoracic surgery.
- •cystic mass .
- •mass with large amount of necrosis or calcification.
- •contraindication of MRI (e.g. pacemakers , claustrophobia).
结局指标
主要结局
sensitivity and specificity of magnetic resonance imaging diffusion in mediastinal masses
时间窗: up to one month
次要结局
未报告次要终点
研究者
Gehad Mohammed Safwat Ali
Principal Investigator
Assiut University