Understanding the prevalence of antibiotic resistance and its treatment in hospital-acquired bloodstream infection cases

Recruiting

• Conditions: Other specified bacterial agents as the cause of diseases classified elsewhere,

• Registration Number: CTRI/2022/09/045558
• Lead Sponsor: Manipal Academy of Higher Education Manipal

Brief Summary

In the present ‘post-antibiotic era’, understanding the prevalence of Carbapenem-resistantGNBs is of utmost importance since it is the first step toward effective antimicrobialstewardship and prevention and control of infection. Awareness regarding the consequence ofCRE infections resulting in high mortality and morbidity and collating the real-world data arecritical as these help in making evidence-based decisions that may improve clinical outcomes.Further, this study will help develop an understanding of the socio-economic implications of the increased average length of hospital stay, loss of income and out-of-pocket expenditures. WHOhas also identified Carbapenem-resistant GNBs as critical pathogens, and data from continuousmonitoring is crucial for urgent drug discovery, research and subsequent developmentprograms. This study will help in understanding the microbiological diagnosis of antibioticresistance, comprehending clinical-microbiological correlation and treatment planning with avery limited arsenal of antibiotics. From this perspective, the study is planned to understand the microbiological nature of bloodstream infections in the laboratory, with a focus on the phenotypic and genotypic determination ofantibiotic resistance and clinical correlation to the treatment outcome.

Detailed Description

Not available

Study Timeline

• Study Start: 2022-09-19
• Last Update Posted: 2022-10-18

Recruitment & Eligibility

• Status: Open to Recruitment
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients admitted to ICU with suspicion of infection or with a blood culture positive report.
• Follow up records available.

Exclusion Criteria

• Patients discharged against medical advice and or follow up not available.
• Adequate blood samples not available for culture.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identification of the prevalence of carbapenem resistance in Enterobacteriaceae.	Baseline

Secondary Outcome Measures

Name	Time	Method
Analysing the patterns of carbapenem resistance in Enterobacteriaceae.	4 weeks

Trial Locations

Locations (1)

Kasturba Medical College; 🇮🇳 Udupi, KARNATAKA, India

Kasturba Medical College

🇮🇳Udupi, KARNATAKA, India

Dr Chiranjay Mukhopadhyay

Principal investigator

9845513057

chiranjay.m@manipal.edu