Fibrinolytic-Associated Urticaria, Angioedema, and Type I Hypersensitivity Reactions from Various Indications
- Conditions
- All fibrinolytic agents either non-fibrin or fibrin specific can cause urticaria,angioedema and type I hypersensitivity reactions owing to their mechanism of actionanaphylaxi hypotension streptokinase tenecteplase tissue plasminogen activator
- Registration Number
- TCTR20190607003
- Lead Sponsor
- o sponsor
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 11
Medical records, either electronic or paper, were reviewed and collected clinical characteristic including gender, age, body weight, baseline systolic and diastolic blood pressure, co-morbidities, medication prior to admission, history of medication allergy, history of prior streptokinase exposure, indications, dosage and administration, premedication strategy, concomitant medications, echocardiogram, electrocardiogram, computed tomography scan, NIHSS score, vital signs, laboratory data. We especially reviewed the medical records of all cases of suspected urticaria, angioedema, and type I hypersensitivity reactions. The following data were extracted: first and last date of fibrinolytic agent usage, onset of suspected reactions, management and clinical outcomes.
No exclusion criteria
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method urticaria, angioedema, and type I hypersensitivity reactions associated with fibrinolytic agents 10 years Retrospective search over a 10-year period, from January 2008, through December 2017
- Secondary Outcome Measures
Name Time Method o secondary outcome No No