Imaging NeuroVascular, Endothelial and STructural Integrity in prepAration to TrEat Small Vessel Diseases - Investigate@SVDs

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 20 人开始时间: 待定最近更新: 2024年2月28日

适应症

试验速览

暂无简介。

•* Symptomatic SVD defined as
•- a history compatible with clinical lacunar stroke syndrome in the last 5
•years with a recent small subcortical infarct visible on MRI scan or CT scan
•compatible with the clinical syndrome.
•-or cognitive impairment defined as visiting a memory clinic and a clinical
•dementia rating score of * 0.5, and capacity to consent with confluent deep WMH
•on MRI (defined on the Fazekas scale as deep WMH score * 2).
•- or a diagnosis of CADASIL established by molecular genetic testing of the
•NOTCH3 gene (presence of an archetypical, cysteine-affecting mutation) or the
•presence of granular osmiophilic material in ultrastructural, electron
•microscopy analysis of skin biopsy.
•* Age 18 years or older
•* Ability to undergo MRI
•* Capacity to give written informed consent
•* Independent in activities of daily living (Modified Rankin score <3)

•* Inclusion criteria are not met
•* Unwillingness or inability to give written consent
•* Pregnant or breastfeeding women, women of childbearing age not taking
•contraception.
•* Contraindications to MRI: pacemaker, metallic foreign body (including
•aneurysm clip in the brain), claustrophobia, pregnancy, neurostimulator,
•pacemaker or other kinds of implanted devices or insulin pump.
•* Contraindications to gadolinium contrast agent used for MRI
•* Other major neurological or psychiatric conditions affecting the brain and
•interfering with the study design (e.g. multiple sclerosis)
•* In case of clinical lacunar stroke syndrome other causes of stroke such as
•*50% luminal stenosis in large arteries supplying the area of ischaemia,
•major-risk cardioembolic source of embolism, other specific causes of stroke
•identified (e.g. arteritis, dissection, migraine/vasospasm, drug misuse)
•* Other stroke risk factor requiring immediate intervention that would preclude
•involvement in the study
•* Renal impairment (eGFR <30 ml/min)
•* Panic disorder

发起方

Medisch Universitair Ziekenhuis Maastricht