Children's Health, Respiratory Inflammation and Short-term Air Pollution
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 330
- 试验地点
- 1
- 主要终点
- "Airway resistance" measured by Oscillometry at R5
研究概览
简要总结
The goal of this study is to see if physical activity in high air pollution is worse than rest in high air pollution.
详细描述
The study will recruit a total of 330 children from 10 primary schools split into two groups: "higher pollution" and "lower pollution" schools. The team shall invite children in years 3 to 6 to take part in the study and consent will be provided by parents following information sheets sent home in school bags and parent evening presentations.
After the team have received written permission from parents. The study team will visit the school on two days. On the first day the study team will perform lung health assessment in a dedicated classroom. The assessment will involve, measuring children's height and weight, a breathing test (photo and a snot sample collected by squirting a small bit of saline water up one nostril and catching the snot in a cup.
Children will then take part in a PE lesson or a sedentary science lesson in a random order in their school playground while wearing activity monitors - like a Fitbit- to track their physical activity. The session is designed to be just like a typical outdoor science or PE lesson and will be exactly the same at all schools. Air pollution levels in the playground will be monitored during this time.
Once the PE lesson has finished the children will perform the same health assessment immediately after the lesson and again on a second day. The team shall compare the change in these scores between higher and lower pollution schools. The breathing tests will tell us if the has been any change in lung health and the snot samples will tell us about the pollution the children have breathed and how their bodies try to fight it. Participating will take about 4 hours total.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 7 Years 至 11 Years(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Attending schools in Central and East London that have been recruited to the study
排除标准
- •Not able to engage with PE lessons on safety grounds, reported by their parents.
- •Children with learning or physical disabilities sufficient for them to be unable to give informed assent to the study, or to carry out study procedures
研究组 & 干预措施
Physical activity
PE Lesson
干预措施: PE Lesson (Behavioral)
Sedenary
Science lesson
干预措施: science lesson (Behavioral)
结局指标
主要结局
"Airway resistance" measured by Oscillometry at R5
时间窗: Pre-24 hour post exposure
measured as oscillometery R5
次要结局
- "Small airway resistance" measured by Oscillometry at R5-20(pre- 24 hour post exposure)
- Immune responses as measured by Il6 in nasal lavage(pre-24 hour post exposure)
