Comparison of Two Neuromuscular Transmission Monitors Based on Acceleromyography: TOF-Watch SX® and TOFScan®
Overview
- Phase
- Not Applicable
- Intervention
- Rocuronium
- Conditions
- Curarisation
- Sponsor
- Central Hospital, Nancy, France
- Enrollment
- 142
- Locations
- 1
- Primary Endpoint
- Time of recovery of the first (T1) response of train of four monitoring displayed on TOFScan and on TOF Watch SX
- Last Updated
- 9 years ago
Overview
Brief Summary
The purpose is to evaluate the reproducibility of neuromuscular monitoring data of recovery from neuromuscular blockade, obtained with TOFScan® and TOF-Watch SX®, in adult and pediatric population.
Secondary purposes are to evaluate the reproducibility of data obtained with 2 monitors for:
- the onset of clinical action of curare: suppression of the first response of train of four monitoring (T1) of 95% initial value
- the duration of clinical action of curare: recovery of the first response of train of four monitoring (T1) to 25% initial value
- recovery of first (T1), second (T2), third (T3) and fourth response (T4) of train of four monitoring, and recovery of T4/T1 to 40% and 60% initial value (T4/T1 0.4 and 0.6)
- complete recovery from curarisation, at T4/T1=90% and T4/T1=100%.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult population:
- •Non opposition to research
- •\> 18 years old
- •ASA score 1-3
- •Undergoing surgery with curarisation through tracheal intubation
- •Affiliation to social security
- •Pediatric population:
- •\> 1 year old
- •Non opposition to research of child (if able to consent) or representatives with parental authority
- •ASA score 1-4
Exclusion Criteria
- •Adult population:
- •Allergy to administered drugs
- •Known or suspected difficult intubation
- •Pregnant women
- •BMI \> 40
- •Pediatric population:
- •Allergy to administered drugs
- •Known or suspected difficult intubation
Arms & Interventions
Adult population 1
TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm
Intervention: Rocuronium
Adult population 1
TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm
Intervention: Neuromuscular monitoring with TOFScan® and TOF-Watch SX®
Adult population 2
TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm
Intervention: Rocuronium
Adult population 2
TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm
Intervention: Neuromuscular monitoring with TOFScan® and TOF-Watch SX®
Pediatric population 1
TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm
Intervention: Rocuronium
Pediatric population 1
TOF-Watch SX® on nondominant arm and TOFScan® on dominant arm
Intervention: Neuromuscular monitoring with TOFScan® and TOF-Watch SX®
Pediatric population 2
TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm
Intervention: Rocuronium
Pediatric population 2
TOF-Watch SX® on dominant arm and TOFScan® on nondominant arm
Intervention: Neuromuscular monitoring with TOFScan® and TOF-Watch SX®
Outcomes
Primary Outcomes
Time of recovery of the first (T1) response of train of four monitoring displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of the second (T2) response of train of four monitoring displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of the third (T3) response of train of four monitoring displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of the fourth (T4) response of train of four monitoring displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of T4/T1 of train of four monitoring at 40% of initial value displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of T4/T1 of train of four monitoring at 60% of initial value displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of T4/T1 of train of four monitoring at 90% of initial value displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Time of recovery of T4/T1 of train of four monitoring at 100% of initial value displayed on TOFScan and on TOF Watch SX
Time Frame: day 0, after induction of anesthesia
Secondary Outcomes
- Time of suppression of the first response of train of four monitoring (T1) at 95% initial value displayed on TOFScan and on TOF Watch SX(day 0, after induction of anesthesia)
- Time of recovery of the first response of train of four monitoring (T1) to 25% initial value displayed on TOFScan and on TOF Watch SX(day 0, after induction of anesthesia)