Randomized Comparison of Fixed Low-dose Combination of THREE Antihypertensive Drugs Versus Fixed High-dose Combination of Two Antihypertensive Drugs in Arterial Hypertension (the 3D Trial)
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of patients who reach target blood pressure
研究概览
简要总结
The aim of the study is to compare the efficacy and safety of low-dose combination of three antihypertensive drugs versus fixed high-dose combination of two antihypertensive drugs in arterial hypertension
详细描述
The aim of the study is to compare the efficacy and safety of commercially available low-dose combination of three antihypertensive drugs versus commercially available fixed high-dose combination of two antihypertensive drugs in arterial hypertension
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with arterial hypertension resistant to monotherapy
排除标准
- 未提供
研究组 & 干预措施
Three antihypertensive Drugs
Patients will be treated with Tripliam, that is a commercially available fixed low-dose combination of three antihypertensive drugs, that is 5 mg/daily perindopril, 1,25 mg/daily indapamide and 5 mg/day amlodipine
干预措施: Tripliam (perindopril, indapamide, amlodipine) (Drug)
Two antihypertensive drugs
Patients will be treated with Reaptan, that is a commercially available fixed high-dose combination of two antihypertensive drugs, that is 10 mg/daily perindopril and 5 mg/day amlodipine
干预措施: Reaptan (perindopril, amlodipine) (Drug)
结局指标
主要结局
Number of patients who reach target blood pressure
时间窗: From baseline to the end of the 3-month study period
How many patients have blood pressure within normal limits
次要结局
未报告次要终点
研究者
Francesco Pelliccia
Assistant Professor
University of Roma La Sapienza