Randomized Comparison of Once-daily Fixed combiNation vErsus freE-drug cOmbination of Three aNtihypertensive Agents in arteriaL hYpertension (the ONE&ONLY Trial)
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Number of patients who reach target blood pressure
研究概览
简要总结
Randomized comparison of once-daily fixed combiNation versus free-drug combination of three antihypertensive agents in arterial hypertension
详细描述
The aim of this randomized study is to compare a once-daily fixed combination pill with a free-drug combination of three antihypertensive agents in arterial hypertension
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with arterial hypertension resistant to monotherapy
排除标准
- 未提供
研究组 & 干预措施
Free combination
Perindopril 10 mg/daily, indapamide 2,5 mg/daily, and amlodipine 10 mg/daily will be given according to a free combination strategy
干预措施: perindopril, indapamide , amlodipine (Drug)
Tripliam
fixed combination of perindopril 10 mg/daily, indapamide 2,5 mg/daily, amlodipine 10 mg/daily
干预措施: Tripliam (perindopril, indapamide, amlodipine) (Drug)
结局指标
主要结局
Number of patients who reach target blood pressure
时间窗: From baseline to the end of the 3-month study period
How many patients have blood pressure within normal limits
次要结局
未报告次要终点
研究者
Francesco Pelliccia
Assistant Professor
University of Roma La Sapienza