Hemodynamic Stability During an Induction of Anaesthesia: A Randomized, Non-blinded Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Incidence of blood pressure drops
研究概览
简要总结
The study aim is to investigate if preoperative volume bolus based on lean body weight could preserve mean arterial pressure during target controlled infusion of anaesthesia (TCI) or rapid sequence induction of anaesthesia (RSI) in non-cardiac, non-morbidly obese surgery.
详细描述
40 individuals are enrolled to TCI and RSI groups respectively. The randomization process for preoperative fluid bolus prior to induction of anaesthesia is conducted in respective group at the day of surgery. Preoperative colloid fluid therapy (6 ml/kg LBW, Gelofusine™, Fresenius Kabi Ab, Sweden) is infused rapidly before non-invasive baseline blood pressure (NIBP) measurements in twenty individuals in each group. No other intravenous fluids before induction of anaesthesia.
NIBPs, pulse frequency, peripheral saturation (SpO2) are registered and collected 20 minutes post induction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •80 individuals over 18 years, body mass index ≤ 35 kg/m2, electively scheduled for breast cancer surgery, endocrinologic surgery (thyroid, parathyroid) and general abdominal surgery.
排除标准
- •instable angina pectoris at the day of surgery, severe bronchial asthma or COPD.
研究组 & 干预措施
No preoperative fluids
40 individuals anesthetized by TCI (n = 20) or RSI (n =20) without preoperative fluids.
Preoperative fluids
40 individuals receiving preoperative colloid fluid bolus at 6 ml/kg LBW, (Gelofusine™, Fresenius Kabi AB, Sweden) before anesthesia induction by TCI (n = 20) or RSI (n =20).
干预措施: gelofusine (Other)
结局指标
主要结局
Incidence of blood pressure drops
时间窗: 20 minutes post anesthesia induction
blood pressure drop below mean arterial pressure at 65 mmHg during anesthesia induction
Effect of preoperative fluid bolus
时间窗: 20 minutes post anesthesia induction
Does preoperative fluid bolus decrease incidence of blood pressure drops
次要结局
未报告次要终点
研究者
Tomi Myrberg
Principal Investigator
Umeå University