Ultrasonographic Assessment of Atelectasis in Major Upper Abdominal Surgeries With Different Ventilatory Strategies
试验速览
- 阶段
- 不适用
- 入组人数
- 117
- 试验地点
- 2
- 主要终点
- Pre-emergence LUS score
研究概览
简要总结
Ventilated Patients especially those undergoing upper abdominal surgeries are prone to lung atelectasis. They are at risk of adverse effects secondary to inadequate lung ventilation.
Applied PEEP and Recruitment maneuver are thought to enhance lung aeration under general anesthesia which could be assessed by ultrasound.
详细描述
The aim of our study is to assess the effect of using PEEP with and without recruitment maneuver on atelectasis and lung aeration during open upper abdominal surgeries by ultrasonography.
Application of PEEP improves intraoperative oxygenation and thus could minimize the incidence of postoperative atelectasis and respiratory complications during abdominal surgeries.
A recent study found that PEEP and RM prevented intraoperative aeration loss, which didn't persist after extubation when comparing effects of positive end-expiratory pressure/recruitment maneuvers with zero end-expiratory pressure on atelectasis during open gynecological surgery by ultrasonography
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Participant, Outcomes Assessor)
盲法说明
Double-blind (Participant, Outcomes Assessor).
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists' physical status grades I, II, and III.
排除标准
- •Patient refusal.
- •Psychiatric diseases.
- •Body Mass Index > 35 Kg/m
- •Previous intrathoracic procedures.
- •History of severe obstructive pulmonary disease.
- •History of severe restrictive lung disease.
- •Pulmonary arterial hypertension ( systolic pulmonary arterial pressure >40 mmHg).
- •Pregnancy.
结局指标
主要结局
Pre-emergence LUS score
时间窗: intraoperative before recovery from anesthesia
Lung ultrasonography score (LUS score) between groups at the end of surgery (just before emergence) as a lower LUS indicates better lung aeration.
次要结局
- Lung ultrasonography score (LUS score)(preoperative, intraoperative for anesthesia duration to 1 hour postoperative)
- Heart rate(preoperative, intraoperative for anesthesia duration to 1 hour postoperative)
- End-tidal carbon dioxide tension(intraoperative for anesthesia duration)
- PaO2/FiO2(Intraoperative and 15 min postoperative)
- Mean blood pressure(preoperative, intraoperative to 1 hour postoperative)
- Arterial partial pressure of carbon dioxide (PaCO2)(Intraoperative and 15 min postoperative)
- Postoperative pulmonary complications (PPCs)(5 days)
- oxygen saturation(preoperative, intraoperative to 1 hour postoperative)
- Arterial partial pressure of oxygen (PaO2)(Intraoperative and 15 min postoperative)
- Peak inspiratory pressure(intraoperative for anesthesia duration)