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Clinical Trials/NCT05636631
NCT05636631
Recruiting
Not Applicable

The Role of Chest Ultrasound in Differentiating Lung Congestion and Pneumonia in Adult Critically-ill Patients and Its Prognostic Impact

Assiut University1 site in 1 country60 target enrollmentNovember 1, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Pneumonia
Sponsor
Assiut University
Enrollment
60
Locations
1
Primary Endpoint
Diagnostic tool
Status
Recruiting
Last Updated
3 years ago

Overview

Brief Summary

This study aim will be to assess the effectiveness of chest ultrasound as a diagnostic and differentiating modality in cases of pneumonia and lung congestion . It also evaluates chests sonography effectiveness in follow-up of patients with pneumonia and lung congestion .

Detailed Description

Lung ultrasound (LUS) is used at the bedside in emergency and critical care settings. It is a rapid and low-cost approach that can direct patient care without the use of harmful radiation. The success of this technique depends on its simplicity to discover the sonographic signs which indicate certain lung pathology. These signs include a hyperechoic and sliding line, moving forward and back with ventilation seen 0.5 cm below the rib line and is called the pleural line. The A-profile associates anterior lung sliding with A lines. A lines are horizontal repetition artifacts of the pleural line. The B-profile associates anterior lung sliding with B lines. B lines appear as shining vertical lines arising from the pleural line and reach the edge of the screen. Several pathological etiologies can fill the alveolar spaces, with fluid (heart failure), pus (pneumonia which is the commonest), blood (pulmonary hemorrhage), and cells (lung cancer). Other causes of lung consolidation may include atelectasis, pulmonary edema, infarction, and lung cancer. Chest imaging with CT is regarded as the gold standard modality allowing for the diagnosis of pneumonia in earlier stage and with higher sensitivity and specificity. On the contrary, cardiogenic pulmonary edema (CPE) is defined as alveolar transudation caused by elevated pulmonary capillary hydrostatic pressure secondary to increased pulmonary venous pressure with low-protein content in the interstitial tissue of lung as a result of cardiac dysfunction

Registry
clinicaltrials.gov
Start Date
November 1, 2022
End Date
July 31, 2025
Last Updated
3 years ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Nardin Aymn Boshra

Doctor

Assiut University

Eligibility Criteria

Inclusion Criteria

  • Adult (above 18 years old)
  • Both genders
  • Patient with symptoms suggestive of pneumonia
  • Patient with symptoms suggestive of acute congestive heart failure
  • admitted to Critical care unit

Exclusion Criteria

  • Patients with Renal induced lung congestion

Outcomes

Primary Outcomes

Diagnostic tool

Time Frame: Baseline

Diagnosis of pneumonia vs lung congestion by using chest ultrasound examination viewing A-lines, B-lines, pleural effusion presence \& its initial amount .

Follow up after initiation of treatment

Time Frame: Baseline ( day 3 of hospital admission)

Follow up of findings of chest U.S on day 1 after initiating therapy using same parameters ( A-lines, B-lines, pleural effusion) on day 3 of hospital admission

Follow up before assessing final outcome

Time Frame: Baseline ( day 7 of hospital admission)

Follow up of findings of chest U.S on day 1 after initiating therapy using same parameters ( A-lines, B-lines, pleural effusion) on day 7 of hospital admission

Secondary Outcomes

  • morbidity & mortality(baseline)

Study Sites (1)

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