Study In NOvel Neuro-muscular Imaging biomarkers for Motor outcome in Stroke (SINONIMS)

ewcastle upon Tyne Hospitals NHS Foundation Trust0 个研究点目标入组 47 人开始时间: 2020年4月22日最近更新: 2023年11月20日

适应症

试验速览

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37941576/ (added 10/11/2023)

•1. Adults aged 18 or over with first-ever unilateral supra-tentorial ischaemic stroke
•2. Unilateral lower limb motor deficit +/- upper limb motor deficit
•3. Less than 4 weeks after stroke onset

•1. Absolute contra-indication to MRI (e.g. pacemaker)
•2. Posterior circulation or haemorrhagic stroke (haemorrhagic transformation of ischaemic stroke is not considered as an exclusion criterion)
•3. Previous history of anterior circulation stroke (clinically or radiologically) or posterior circulation stroke with residual clinical deficit
•4. Lack of capacity to provide informed consent
•5. Unable to transfer independently or with assistance of one person if scanned in Newcastle University or with assistance of two people if scanned in Royal Victoria Infirmary
•6. Unable to answer MRI safety questionnaire
•7. Moderate to high level of dependency prior to stroke (modified Rankin score of >2)
•8. Any other pre-existing co-morbidity causing a significant lower limb deficit

发起方

ewcastle upon Tyne Hospitals NHS Foundation Trust