NCT02062008TerminatedNot Applicable
Validation of Combined PET-MR Quantitative Parameters for Cardiac Applications
University of California, San Francisco1 site in 1 country2 target enrollmentStarted: December 1, 2016Last updated:
Conditions
Interventions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Enrollment
- 2
- Locations
- 1
- Primary Endpoint
- Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
Study Overview
Brief Summary
The purpose of this study is to understand how simultaneous PET/MR acquisition can provide novel qualitative and quantitative biomarkers to guide clinical intervention and predict prognosis of patients with cardiovascular disease.
Detailed Description
- To compare regional myocardial uptake of FDG on images obtained on a standard PET camera with the new PET/MR camera, in patients with coronary artery disease.
- To compare viability maps obtained with cardiac MR images and FDG-PET for delineation of myocardial infarct core and border zone, in patients with coronary artery disease.
- To correlate MRI myocardial strain with relative myocardial FDG uptake in patients with a previous myocardial infarction.
- To interrogate if simultaneous acquisition of cardiac PET and viability cardiac MR differ from acquisitions obtained independently, with special focus on attenuation correction methods
- To combined MRI scar map with FDG-PET uptake in patients with cardiac sarcoidosis and myocarditis.
- To correlate morphologic characteristics of atherosclerotic disease in the thoracic and abdominal aorta with FDG uptake and ferumoxytol enhancement, as a marker of inflammation.
- To evaluate cardiac strain and myocardial scar burden in obese patients with and without diabetes.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Diagnostic
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Subjects with ischemic and non-ischemic cardiac disease referred for cardiac PET for viability imaging.
Exclusion Criteria
- •Contraindications for MRI, including cardiac pacemaker, claustrophobia, retained metallic foreign body, cochlear implant, Aneurysm clip in the brain, pregnancy and eGFR less than 45%.
Arms & Interventions
Cardiac patients receiving PET/MR
Other
PET-MRI with intravenous Gadolinium and FDG. The entire study will take approximately one hour.
Intervention: PET-MRI (Device)
Outcomes
Primary Outcomes
Number of Quality PET and PET/MR Images With Regional Myocardial Uptake of 18F-Fluorodeoxyglucose (FDG) in Participants Without Overt Diagnosis of Ischemic Coronary Artery Disease.
Time Frame: 2 hours
Visual analysis of collected image pairs. Evaluated by experienced imaging providers as yes or no.
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
Loading locations...
Similar Trials
Completed
Not Applicable
PET-MR for Prediction and Monitoring of Response to Neoadjuvant Chemotherapy in Breast CancerBreast CancerNCT01190566Seoul National University Hospital57
Recruiting
Phase 1
Biologic Association Between Metabolic Magnetic Resonance-positron Emission Tomograph (MR-PET) and Tissue Measures of Glycolysis in Brain Tumors of Infiltrating Glioblastoma CellsGlioblastoma MultiformeGlycolytic IndexEpidermal Growth Factor ReceptorNCT06059690Jonsson Comprehensive Cancer Center50
Terminated
Not Applicable
PET/MR Characterization of Renal Cell CarcinomasRenal Cell CarcinomaNCT04271254UNC Lineberger Comprehensive Cancer Center5
Completed
Not Applicable
The New Combined PET-MR System NextGen PET-MR With Syngo MR XA80A: Evaluation of Diagnostic Image Quality and Usability (Software and Hardware) in the Clinical Setting.The Evaluation of a New MD - Combined PET-MR SystemNCT06666387Siemens Healthcare A/S65
Completed
Not Applicable
Simultaneously PET/MRI in Prolonged DOC PatientsDisorder of ConsciousnessFDG-PETMinimally Conscious StateRs-fMRINCT04164680Hangzhou Normal University24