New Prognostic Kidney Function Markers in Emergency Patients New Markers of Kidney Function in ED Patients

Withdrawn

• Conditions: Contrast Media; Acute Kidney Injury

• Registration Number: NCT02261909
• Lead Sponsor: Krankenhaus Barmherzige Brüder, Regensburg

Brief Summary

NephroCheck is measuring the concentration of a certain protein combination in the urine of patients. In elevated values there is a probability of renal failure (already proven in intensive care patients). The investigators would like to investigate whether the investigators can predict renal failure in patients receiving contrast enhanced CT's in the emergency department. That would lead to an earlier nephrologist consult in those patients.

Detailed Description

The use of contrast agents can - especially in already in impaired renal function - lead to a decline in real function. The contrast enhanced CT is especially in emergency patients an important diagnostic tool for example in the detection of pulmonary embolism or mesenteric ischemia. Creatinine has been used as a marker for real function so far. But the investigators all know that creatinine is not a perfect marker especially as it is influenced by age, sex, weight and muscle mass. Especially in the diagnosis of acute renal failure creatinine does not allow and recent change in the kidney function.

This prospective, unicentric study should therefore investigate two new markers in emergency patients who need an emergency contrast enhanced CT to early predict pending kidney function decline.

Study Timeline

• Study First Submitted: 2014-10-03
• Study First Submitted QC: 2014-10-09
• Study First Posted: 2014-10-10
• Study Start: 2015-05
• Primary Completion: 2016-05
• Study Completion: 2016-06
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-18
• Last Update Posted: 2022-08-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• patients in the emergency department who have the indication for contrast enhanced CT and a predicted hospital admission time of 48 hours or longer.

Exclusion Criteria

• children, pregnant women
• dialysis
• patients with kidney transplants
• patients on steroids or further immunocompromised

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal function	participants will be followed for the duration of hospital stay, an expected average of 7 days	renal function at discharge from hospital (creatinine and BUN measured at day of discharge)

Secondary Outcome Measures

Name	Time	Method
Requirement for dialysis	participants will be followed for the duration of hospital stay, an expected average of 7 days	dialysis required throughout hospital stay
Admission to ICU	participants will be followed for the duration of hospital stay, an expected average of 7 days	admission to ICU required throughout hospital stay

Trial Locations

Locations (1)

Krankenhaus Barmherzige Brueder; 🇩🇪 Regensburg, Bavaria, Germany