Comparison of the Effect of Aprepitant with Ondansetron on PONV

Phase 2

Recruiting

• Conditions: Postoperative Nausea and Vomiting after Orthognathic Surgery.; Nausea and vomiting following gastrointestinal surgery; R11(K91.0)

• Registration Number: IRCT20211205053279N3
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 7 February 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Age 15-50 year
American Society of Anesthesiologist physical statous I_II
weight 40-90 Kg
apfel scale =2
posted for orthognathic surgery under general anaesthesia

Exclusion Criteria

Pregnancy/breastfeeding status
Allergy to any medications to be used before operation or intra-operatively
History of drug abuse
Patients with hystory of heart, renal, or hepatic failure

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The incidence of post operative nausea. Timepoint: Before the intervention, when the patient enters the Post Anesthesia Care Unit, 2 hours after surgery, 6 hours after surgery, 12 hours after surgery, 24 hours after surgery, and 48 hours after surgery. Method of measurement: Verbal rating scale.;The incidence of post operative vomiting. Timepoint: Before the intervention, when the patient enters the Post Anesthesia Care Unit, 2 hours after surgery, 6 hours after surgery, 12 hours after surgery, 24 hours after surgery, and 48 hours after surgery. Method of measurement: Verbal rating scale.