Comparing response of Aprepitant and Ondansetron with only Aprepitant in Post operative nausea and vomiting in craniotomy patients.
Not Applicable
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/04/032588
- Lead Sponsor
- DEPARTMENT OF ANAESTHESIOLOGY AND CRITICAL CARE JNMC ALIGARH MUSLIM UNIVERSITY
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
American Society of Anesthesiologists(ASA) physical status I & II patients of either sex scheduled to undergo elective craniotomy under General Anaesthesia.
Exclusion Criteria
(1) Patients with a history of motion sickness or gastrointestinal disease.
(2) Patients receiving antiemetics within 24 hours before surgery, (except Dexamethasone).
(3) Patients with cardiovascular disease like coronary artery disease, hypertension, etc.
(4) Pulmonary disease like asthma, COPD, cor-pulmonale.
(5) Patients with neuro-muscular, hepatic or major renal disease.
(6) History of alcohol, drug abuse or smokers.
(7) History suggestive of hiatus hernia/GERD.
(8) GCS less than 13.Â
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To measure the incidence of Post-Operative Nausea and Vomiting during first 24 hours after surgery.Timepoint: 24 hours after surgery
- Secondary Outcome Measures
Name Time Method 1.Severity of nausea and vomiting. <br/ ><br>2.Number of emetic episodes. <br/ ><br>3.Incidence of complete response. <br/ ><br>4.Patient Satisfaction Score. <br/ ><br>5.Timing of first dose of rescue anti emetic. <br/ ><br>6.Time to first emetic episode. <br/ ><br>7.Timing of first dose of rescue analgesic. <br/ ><br>8.Incidence of side effects. <br/ ><br>Timepoint: 24 hours