IL-6 in Exercise-Induced Anorexia

Not Applicable

Completed

• Conditions: Appetitive Behavior; Pediatric Obesity
• Interventions: Other: High Intensity Exercise/Ibuprofen

• Registration Number: NCT03295968
• Lead Sponsor: University of Toronto

Brief Summary

This study investigates the effect of high intensity exercise, with and without the inflammation inhibitor, ibuprofen, on plasma levels of IL-6 and other selective biomarkers of inflammation and appetite on food intake and subjective ratings of appetite in normal-weight boys.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-03
• Primary Completion: 2016-10
• Study Completion: 2016-10
• Status Verified: 2017-09
• Study First Submitted: 2017-09-22
• Study First Submitted QC: 2017-09-27
• Last Update Submitted: 2017-09-27
• Study First Posted: 2017-09-28
• Last Update Posted: 2017-09-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 15

Inclusion Criteria

• 13-18 yrs, healthy, male

Exclusion Criteria

• female, heamatophobia, following a diete, diagnosed with diabetes or other metabolic diseases, scoring ≥11 on an Eating Habit Questionnaire

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Water and High Intensity Exercise	High Intensity Exercise/Ibuprofen	-
Ibuprofen and Rest	High Intensity Exercise/Ibuprofen	-
Ibuprofen and High Intensity Exercise	High Intensity Exercise/Ibuprofen	-

Primary Outcome Measures

Name	Time	Method
Food Intake	100-120 min	Participants were provided with ad libitum lunch meal, consisting of rice (Uncle Ben's, Bolton, ON, Canada), beef meatballs (President's Choice, Brampton, ON, Canada) and tomato sauce (Ragu, Mount Prospect, IL, USA) at 100 - 120 min. The meatballs were cut into small and uniform pieces and were mixed homogeneously with the other ingredients in a bowl. One bowl was a 479.5 g portion which represented 827.5 kcal, 30.8 g fat, 104.8 g carbohydrate and 30.2 g protein based on the weight consumed and the compositional information provided by the manufacturers. Two portions we served in 10 min intervals and FI from the pizza meal was calculated based on the weight consumed during the lunch. Participants were instructed to eat until comfortably and stay seated during the duration of the meal.
Visual Analog Scale Appetite Scores	0-120min	Visual Analog Scales were employed to assess subjective appetite based on the following questionnaires: Determination to Eat, Hunger, Fullness and Prospective Food Consumption.
Appetite Biomarkers	0-120min	Active Ghrelin, Blood Glucose, Insulin, Peptide-YY and Glucagon-like peptide-1 were determined as appetite biomarkers.
Inflammatory and Stress Biomarkers	0-120min	Interleukin-6, Tumor necrosis factor alpha and cortisol were determined as appetite biomarkers.

Trial Locations

Locations (1)

University of Toronto; 🇨🇦 Toronto, Ontario, Canada