Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Young Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 56
- 试验地点
- 2
- 主要终点
- Change in acute myofibrillar protein synthesis rates
研究概览
简要总结
This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in untrained men and women ages 18-30
详细描述
This is a two-phase study using both novel and conventional methods to assess how PP supplementation affects muscle tissue in young adults who engage in resistance training. These two phases will be conducted as part of a 10-week randomized controlled trial in which men and women aged 18-30 years (n=40), will be stratified by gender and randomized to a resistance training intervention (whole body, two days per week) with PP powder (72g daily; n=10 males, n=10 females) provided during the intervention (immediate group, IG) or after the intervention (wait-list control, WLC, n=10 males, n=10 females). The aims of this study are to determine the acute (deuterium oxide tracer) and chronic (peripheral quantitative computed tomography) effects of PP during resistance training on skeletal muscle myofibrillar protein synthesis rates, changes in skeletal muscle size and quality, changes in whole and appendicular body composition (dual energy x-ray absorptiometry), changes in inflammatory markers and the fecal microbiome.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
PI and Co-Is will be blind to participant randomization. One study staff member will be responsible for administering the supplements to participants per randomization
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •body mass index (body mass/height squared) less than 35 kg/m2
- •resting blood pressure averaging less than 140/90 mmHg (with or without medication)
排除标准
- •known peanut allergy
- •actively participating in resistance training for more than 2 days/week
- •any known overt cardiovascular or metabolic disease
- •metal implants that will interfere with x-ray procedures
- •medically necessary radiation exposure in the last six months (except dental x-ray)
- •any medical condition that would contradict participating in an exercise program, giving blood or donating a skeletal muscle biopsy (i.e. blood clotting disorder or taking blood thinners)
- •pregnant or trying to become pregnant
结局指标
主要结局
Change in acute myofibrillar protein synthesis rates
时间窗: 24 hours
Change in right leg vastus lateralis myofibrillar protein synthesis rates using the integrated deuterium oxide technique from biopsies immediately before and 24 hours after resistance exercise Change in right leg vastus lateralis myofibrillar protein synthesis rates using the integrated deuterium oxide technique from biopsies immediately before and 24 hours after resistance exercise
Change in mid-thigh skeletal muscle area and quality
时间窗: 0-10 weeks
Peripheral quantitative computed tomography (pQCT) cross-sectional image of mid-right thigh assessed for overall muscle density (mg/cm\^3)
次要结局
- Change in Type I and II Muscle Fiber Cross-Sectional Area(0-10 weeks)
- Change in leg extensor isokinetic dynamometry(0-10 weeks)
- Change in fecal microbiome composition(0-10 weeks)
- Change in appendicular lean mass(0-10 weeks)
研究者
Andrew Fruge
Assistant Professor
Auburn University