Gastrointestinal Ischemia in Acute and Chronic Portal Vein Thrombosis

Recruiting

Conditions: portal vein obstruction
thrombosis of the portal vein
10018031
10019654
10014523

Registration Number: NL-OMON39226

Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

- Unambiguous evidence of complete thrombosis of the main portal vein (endoluminal material and absence of flow or presence of cavernous transformation), as detected by proper imaging techniques (duplex ultrasound, computerised tomography (CT), magnetic resonance imaging (MRI) or venography).
- Date of diagnosis after 01-01-2000
- Age >18 years
- Signed informed consent;Controlgroup:
- >18 years
- Signed informed consent
- Patients with liver corrhosis and portal hypertension
- Patent mesentery arteries and veins

Exclusion Criteria

- Liver cirrhosis
- Malignancy
- No informed consent
- Pregnant or lactating women;Controlgroup:
- <18 years
- No informed consent
- Stenosis/thrombosis of the mesentery arteries and veins
- Presence of an open intrahepatic shunting stent (i.e. TIPS)

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence of gastrointestinal ischemia in patients with non-cirrhotic,<br /><br>non-malignant PVT.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Evaluation of cardiovascular risk factors<br /><br>- Evaluation of small bowel function using a sugar-absorption test (SAT)<br /><br>- Comparison of visible light spectroscopy with findings at duplex ultrasound<br /><br>examination<br /><br>- Prevalence of gastrointestinal ischemia in patients with acute and chronic PVT<br /><br>- Prevalence of gastrointestinal ischemia in patients with an extended<br /><br>thrombosis of the portal vein (i.e. additional thrombosis of the superior<br /><br>mesenteric vein), as detected by duplex ultrasound<br /><br>- Relationship between diagnosis of gastrointestinal ischemia and symptoms<br /><br>- Comparison of mucosal saturation measurements using VLS between patients with<br /><br>PVT and patients with liver cirrhosis and portal hypertension with patent<br /><br>mesentery arteries and veins</p><br>