EMPIRE-Elafin Myocardial Protection from Ischaemia RepErfusion injury - Effect of elafin on myocardial injury

HS Lothian0 sites80 target enrollmentApril 15, 2011

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Myocardial ischaemia reperfusion injury Post-operative inflammation Post-ischaemic inflammatory injury
Sponsor: HS Lothian
Enrollment: 80
Status: Active, not recruiting
Last Updated: 6 years ago

No summary available.

Registry

who.int

Start Date

April 15, 2011

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional clinical trial of medicinal product

Sponsor

HS Lothian

•Patients who are referred for coronary artery bypass graft surgery requiring 2 or more grafts will be approached for consent to enter the study during visits to the cardiothoracic surgery outpatient clinic.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1\.2 Adults (18\-64 years) yes
•F.1\.2\.1 Number of subjects for this age range
•F.1\.3 Elderly (\>\=65 years) yes
•F.1\.3\.1 Number of subjects for this age range

•The following exclusion criteria will apply: Contraindication to MRI scanning Emergency surgery Recent myocardial infarction (a recorded troponin elevation within 1 month of surgery) Concomitant valve or aortic surgery Re\-intervention or re\-do surgery Chronic renal failure (estimated glomerular filtration rate \<40 ml/min) Severe respiratory disease maintenance corticosterod therapy or forced expiratory volume on one second (FEV1\) \< 50% predicted Congestive cardiac failure A history of chronic inflammatory illness Patients unable to give informed consent will not be approached.