EUCTR2010-019527-58-GBActive, not recruitingPhase 1
EMPIRE-Elafin Myocardial Protection from Ischaemia RepErfusion injury - Effect of elafin on myocardial injury
HS Lothian0 sites80 target enrollmentStarted: April 15, 2011Last updated:
Conditions
Drugs
Trial Snapshot
- Phase
- Phase 1
- Status
- Active, not recruiting
- Sponsor
- Enrollment
- 80
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional clinical trial of medicinal product
Eligibility Criteria
Inclusion Criteria
- •Patients who are referred for coronary artery bypass graft surgery requiring 2 or more grafts will be approached for consent to enter the study during visits to the cardiothoracic surgery outpatient clinic.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range
Exclusion Criteria
- •The following exclusion criteria will apply: Contraindication to MRI scanning Emergency surgery Recent myocardial infarction (a recorded troponin elevation within 1 month of surgery) Concomitant valve or aortic surgery Re-intervention or re-do surgery Chronic renal failure (estimated glomerular filtration rate <40 ml/min) Severe respiratory disease maintenance corticosterod therapy or forced expiratory volume on one second (FEV1) < 50% predicted Congestive cardiac failure A history of chronic inflammatory illness Patients unable to give informed consent will not be approached.
Investigators
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