Mutations of Glucocorticoid Receptor in Bilateral Adrenal Hyperplasia
- Conditions
- General Glucocorticoid Resistance
- Interventions
- Genetic: blood collection for mutation characterization
- Registration Number
- NCT02810496
- Lead Sponsor
- CHU de Reims
- Brief Summary
As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 150
- patients more than 18 years of age
- patients with bilateral adrenal masses
- Refusing to participate in the study
- Protected by law
- Have obvious signs of Cushing's syndrome
- No progressive neoplastic disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description patient blood collection for mutation characterization -
- Primary Outcome Measures
Name Time Method frequency of mutations DAY 0
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Chu Reims
🇫🇷Reims, France