Impact of Operating Room Extubation on Postoperative Outcomes in Neonates Undergoing Meningomyelocele Repair: A Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Postoperative Mechanical Ventilation Requirement
研究概览
简要总结
Meningomyelocele is one of the most common neural tube defects requiring surgical repair in the neonatal period. Postoperative respiratory complications and the need for prolonged mechanical ventilation are important causes of morbidity in these patients. The timing of extubation may influence postoperative respiratory outcomes and the duration of neonatal intensive care unit (NICU) stay. This retrospective cohort study aims to evaluate the impact of operating room extubation on postoperative outcomes in neonates undergoing meningomyelocele repair at Gaziantep City Hospital. Clinical, laboratory, and perioperative data will be obtained from hospital records. Postoperative mechanical ventilation requirement, duration of ventilation, NICU length of stay, and perioperative laboratory changes will be compared between neonates extubated in the operating room and those extubated in the intensive care unit.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 0 Days 至 28 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Neonates undergoing surgical repair of meningomyelocele
- •Surgery performed under general anesthesia
- •Age ≤ 28 days at the time of surgery
- •Postoperative follow-up in the neonatal intensive care unit (NICU)
- •Availability of complete perioperative clinical and laboratory data
排除标准
- •Preoperative respiratory distress requiring invasive or non-invasive ventilatory support
- •Major congenital anomalies or severe comorbidities (e.g., complex congenital heart disease, severe pulmonary disease, chromosomal abnormalities)
- •Neonates with poor postnatal adaptation (5-minute Apgar score < 7)
- •Preoperative hemodynamic instability
- •Severe prematurity-related respiratory morbidity
- •Prolonged mechanical ventilation due to causes unrelated to meningomyelocele surgery
- •Incomplete or missing perioperative medical records
研究组 & 干预措施
Operating Room Extubation
Neonates who were extubated in the operating room immediately after meningomyelocele repair.
ICU Extubation
Neonates who were transferred intubated to the NICU and extubated in the intensive care unit after meningomyelocele repair.
结局指标
主要结局
Postoperative Mechanical Ventilation Requirement
时间窗: Within the first 48 hours after surgery
Requirement for invasive mechanical ventilation after meningomyelocele repair in neonates.
次要结局
- Length of NICU Stay(From surgery until discharge from the neonatal intensive care unit, up to 30 days)
- Change in Blood pH(Preoperative vs postoperative 24 hours)
- Change in Lactate Level(Baseline (preoperative) and 24 hours after surgery)
研究者
Recep Karakaşoğlu
Specialist in Anesthesiology and Reanimation
Gaziantep City Hospital