Enhanced Diagnostics of Encephalitis by the use of Next-Generation Sequencing
- Conditions
- G05Encephalitis, myelitis and encephalomyelitis in diseases classified elsewhere
- Registration Number
- DRKS00015835
- Lead Sponsor
- Westpfalz-Klinikum Kaiserslautern
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 50
• declaration of consent signed by participant of the clinical trial or the participant’s legal representative
• age > 18 years
• encephalitis: suspected inflammation of brain tissue that is accompanied by neurological dysfunction
• lying or indicated CSF (Cerebrospinal fluid) drainage
• age < 18 years
• refusal of participation
• transfer from intensive care unit in the first 72h after beginning of clinical trial is very likely
• palliative therapy
• limitation of therapy possible
• death of patient is already in the beginning of clinical trial predictable and seems unavoidable
• patients, that have been included in the study and are retransferred to the intensive care unit, can’t be included a second time
• pregnancy
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Microbial detection from CSF-samples (Cerebral spinal fluid) by use of NGS (Next-Generation Sequencing)<br>- Comparison with blood culture<br>- CSF-samples and blood-sampled are drawn at a particular time
- Secondary Outcome Measures
Name Time Method - Evaluation of results using SIQ (Sepsis Indicating Quantifier) Score<br>- aim of clinical trial: new approaches for future diagnostics of encephalitis for patients under intensive care <br>