EIT-guided PEEP Titration Versus Low PEEP/FiO2 Table for ARDS: a Multicenter, Randomized, Controlled Trial

Peking Union Medical College Hospital1 site in 1 country676 target enrollmentApril 10, 2022

ConditionsARDS, Human

InterventionsEIT-guided PEEP Table-guided PEEP

Overview

Phase: Not Applicable
Intervention: EIT-guided PEEP
Conditions: ARDS, Human
Sponsor: Peking Union Medical College Hospital
Enrollment: 676
Locations: 1
Primary Endpoint: Survival in 28 days
Status: Completed
Last Updated: 3 months ago

Overview Investigators Eligibility Criteria Arms & Interventions Outcomes Sites Similar Trials

Overview

Brief Summary

This study is a multicentric randomized controlled study.The objective of this study is to compare the prognosis of patients with ARDS between EIT-oriented individualized PEEP and traditional lower PEEP/FiO2 table-oriented PEEP strategy.

Registry

clinicaltrials.gov

Start Date

April 10, 2022

End Date

May 10, 2025

Last Updated

3 months ago

Study Type

Interventional

Study Design

Parallel

Sex

All

Investigators

Sponsor

Peking Union Medical College Hospital

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Intubated, mechanically ventilated patients with diagnosis of ARDS according to ARDS Berlin standard by attending doctor

Exclusion Criteria

•Age \< 18 years old and \> 90 years old;
•EIT contradictions (presence of pacemaker or automatic implantable cardioverter defibrillator);
•Severe intracranial hypertension;
•Pneumothorax, pneumomediastinum, subcutaneous emphysema or at high-risk for pneumothorax (e.g., pneumatocele, interstitial lung disease);
•Unstable hemodynamic status intorerable to lung recruitment and PEEP titration, judged by an attending intensivist; (This may be a transient criterion, since patients meeting this criterion might be included later if hemodynamics improves)
•End status of disease;
•Patients or their families refused to participate in the study