NCT01737190Unknown不适用
PEEP Guided by Esophageal Balloon Measurement and Its Effect on Recruitment Maneuver
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- oxygenation
研究概览
简要总结
The aim of the study is to examine the effects of two different levels of PEEP on subsequent standard recruitment maneuver.
详细描述
In this study we will examine the effects of two levels of PEEP on subsequent recruitment maneuver. In the first group a recruitment maneuver will be performed in patients who are ventilated with PEEP level set according to the ARDS network algorithm.
Patients will then be crossed over to a study arm where another recruitment maneuver will be performed while PEEP is adjusted according to esophageal pressure measurements.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •20 Man and women older than 18 years will be recruited.
- •Patients with acute respiratory failure of any cause who are mechanically ventilated according to the ARDS network recommendations will be considered for inclusion to the study.
- •To be included in the study a prerequisite of high peak Inspiratory pressure (plateau pressure of 25 to 30 cmH2O) has to be present, and at least one of the following four severity inclusion criteria has to be met.
- •1 - Low Total Respiratory system compliance (CT), defined as less than 50ml/cmH2O. 2 - PaO2 /FIO2 ratio of less than
- •3 - Need for a PEEP greater than 10 cmH2O to maintain SaO2 of > 90%. 4 - PCO2 over 60 mmHg, or PH less than 7.2 that is attributed to respiratory acidosis.
排除标准
- •Patients with any of the following will be excluded from the study. Previous lung or chest wall surgery, previous esophageal surgery, known Achalasia or any other esophageal motility or spasm disorder, presence of chest thoracostomy tube, and any significant chest wall abnormality such as kyphoskoliosis.
结局指标
主要结局
oxygenation
时间窗: 4 hours
the primary end point in both groups will be oxygenation improvement after each intervention in each arm.
次要结局
- lung compliance(4 hours)
研究者
Soroksky Arie
Dr.
Wolfson Medical Center
研究点 (2)
Loading locations...
相似试验
已完成
不适用
Comparison of the effects of different PEEP (positive end-expiratory pressure) levels on cerebral oxygen saturation in patients undergoing laparoscopic cholecystectomyCO2 pneumoperitoneumCerebral oxygen saturationAnaesthesiology - Other anaesthesiologySurgery - Surgical techniquesACTRN12615000581561Konya Training and Research Hospital105
已完成
不适用
PEEP Levels on Intraabdominal Pressure and Hemodynamics in Critically Ill PatientsIntraabdominal HypertensionCritically IllHemodynamic InstabilityNCT03714724Yuzuncu Yıl University66
终止
不适用
Esophageal Balloon Guided Weaning of the Morbidly Obese PatientMorbid ObesityNCT02323009East Carolina University25
已完成
不适用
Effect of Endoscopic Papillary Balloon Dilation on ERCP ComplicationsComplicationsNCT02510495Hepatopancreatobiliary Surgery Institute of Gansu Province1,920
已完成
不适用
Effect of PEEP on Gastric Insufflation During Face Mask Induction of General Anesthesia in ChildrenAnesthesiaChildNCT06127173Kasr El Aini Hospital72