Shear Stress in the Arteries of the Lower Limbs During Exercise in Patients With Peripheral Arterial Disease
- Conditions
- Peripheral Arterial Disease
- Registration Number
- NCT06068504
- Lead Sponsor
- University of Nove de Julho
- Brief Summary
The aim of the study will be to evaluate shear stress and blood flow parameters in lower limb arteries during arm cycle ergometer exercise in participants with peripheral artery disease. Twenty patients participants with peripheral artery disease and claudication symptoms will be recruited. Participants will perform 3 experimental sessions in random order. Iarm-cranking (15 sets of two minutes exercise), warm water foot immersion, and control. During the interventions, blood pressure and heart rate will be assessed every 6 minutes. Measurements of arterial diameter, blood flow, anterograde and retrograde shear stress of the femoral artery will be evaluated using a two-dimensional ultrasound device with spectral Doppler.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 20
- clinical diagnosis of peripheral artery disease or ankle-brachial index less than 0.90 in one or both limbs
- do not present peripheral neuropathy;
- be able to exercise after medical approval
- aged 50 or over.
- Medication change during the study
- Health problems that contraindicates the practice of physical exercise.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Femoral artery Blood flow [mL/min] Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention Measurements will be obtained through duplex ultrasound in accordance with global recommendations.
Femoral artery diameter [mm] Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention Measurements will be obtained through duplex ultrasound in accordance with global recommendations.
Femoral artery shear rate [sec.-1] Before the intervention and at 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, 26, 28, and 30 minutes into the intervention Measurements will be obtained through duplex ultrasound in accordance with global recommendations.
- Secondary Outcome Measures
Name Time Method Brachial systolic and diastolic blood pressure [mmHg] Before the intervention and at 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21, 23, 25, 27, and 29 minutes into the intervention Systolic and diastolic blood pressures will be assessment in the arms with an automatic blood pressure monitor (HEM-742, Omron Healthcare, Japan)
Heart rate [bpm] Before and up to 30 minutes into the intervention Heart rate assessment with a heart rate monitor (Polar H10, Polar®, Finland)
Related Research Topics
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Trial Locations
- Locations (1)
University Nove de Julho
🇧🇷São Paulo, Brazil
University Nove de Julho🇧🇷São Paulo, Brazil