The Role of Endogenous GLP-1 (Glycolipoprotein) in Regulating Glucose Stimulated Brain Activity

Not Applicable

Completed

• Conditions: Exploratory Behavior
• Interventions: Dietary Supplement: 300ml tap water with 450ppm lactisole; Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube; Dietary Supplement: Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole; Dietary Supplement: 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39; Dietary Supplement: tap water; Dietary Supplement: 25g Fructose in 300ml tap water

• Registration Number: NCT01918566
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

Our objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI. Administration of glucose with and without lactisole and exendin as well as fructose is followed by functional brain MRI, and findings are correlated with serum GLP-1 levels as an endogenous satiety signal in humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2013-03
• Study Completion: 2013-03
• Study First Submitted: 2013-05-08
• Status Verified: 2013-08
• Study First Submitted QC: 2013-08-05
• Last Update Submitted: 2013-08-05
• Study First Posted: 2013-08-07
• Last Update Posted: 2013-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• right-handed healthy males, no drugs, non-smoking

Exclusion Criteria

• drug abuse, smoker, left-handed, claustrophobia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
tap water, lactisole	300ml tap water with 450ppm lactisole	Single intragastric instillation of 300ml tap water with 450ppm lactisole
Glucose	Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube	Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube
Glucose plus Lactisole	Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole	Single intragastric instillation of 75g Glucose in 300ml tap water with 450ppm lactisole
Glucose and Exendin	75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39	Single intragastric instillation of 75g glucose in 300ml tap water with 600pmol/kg/min exendin 9-39
300ml tap water	tap water	Single intragastric instillation of 300ml tap water via nasogastric tube
Fructose	25g Fructose in 300ml tap water	Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube

Primary Outcome Measures

Name	Time	Method
Functional magnetic resonance imaging (fMRI) in healthy volunteers while they performed a working memory task: changes in cerebral blood flow and blood hormones from baseline to treatment	changes from baseline to one hour after treatment	Whole brain analysis with a cluster-level threshold was followed by an a priori defined region of interest analysis of the dorsolateral prefrontal cortex including a cluster-level threshold and family-wise error adjustment for multiple comparisons.

Trial Locations

Locations (1)

University Hospital; 🇨🇭 Basel, Switzerland