Glucose and Fructose Stimulated Brain Activity in Obese Subjects Before and After Bariatric Surgery

Not Applicable

Completed

• Conditions: Exploratory Behavior
• Interventions: Dietary Supplement: Tap water; Dietary Supplement: Fructose; Dietary Supplement: Glucose

• Registration Number: NCT02902224
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

The objective is to investigate neuro-anatomical correlates of the regulation of energy intake by means of functional MRI before and after bariatric surgery. Administration of glucose as well as fructose is followed by functional brain MRI, and findings are correlated with serum glucagon-like peptide 1 (GLP-1) levels as an endogenous satiety signal in obese humans.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-04
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2016-09
• Study First Submitted: 2016-09-12
• Study First Submitted QC: 2016-09-12
• Last Update Submitted: 2016-09-12
• Study First Posted: 2016-09-15
• Last Update Posted: 2016-09-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• right-handed
• morbidly obese patients
• scheduled for bariatric surgery

Exclusion Criteria

• Diabetes mellitus
• cardiovascular disease
• neurologic or psychiatric disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
PLACEBO	Tap water	Single intragastric instillation of 300ml tap water via nasogastric tube
FRUCTOSE	Fructose	Single intragastric instillation of 25g Fructose in 300ml tap water via nasogastric tube
GLUCOSE	Glucose	Single intragastric instillation of 75g Glucose in 300ml tap water via nasogastric tube

Primary Outcome Measures

Name	Time	Method
Functional magnetic resonance imaging (fMRI) in healthy, obese volunteers while they performed a working memory task: changes in cerebral blood flow	changes from baseline to one hour after treatment

Secondary Outcome Measures

Name	Time	Method
Changes in plasma insulin	Changes from baseline to one hour after treatment
Changes in plasma glucose	Changes from baseline to one hour after treatment
Changes in Plasma GLP-1	Changes from baseline to one hour after treatment

Trial Locations

Locations (1)

University Hospital Basel; 🇨🇭 Basel, Switzerland