Basal Tumours in Bladder Cancer, Response to chemoTherapy

Completed

• Conditions: Bladder Cancer; Chemotherapy Effect

• Registration Number: NCT04089748
• Lead Sponsor: University Hospital, Rouen

Brief Summary

Determine the sensitivity/resistance to chemotherapy of the various subgroups of muscle-invasive bladder cancers, including the basal subgroup (about 25% of these tumours) according to 4 different classifications based on molecular or immunohistochemical classifiers.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-02-27
• Primary Completion: 2019-04-29
• Study Completion: 2019-04-29
• Study First Submitted: 2019-09-04
• Study First Submitted QC: 2019-09-12
• Study First Posted: 2019-09-13
• Status Verified: 2025-06
• Last Update Submitted: 2025-06-02
• Last Update Posted: 2025-06-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 293

Inclusion Criteria

Not provided

Exclusion Criteria

-Patients enrolled in VESPER study:Tumors from patient having withdrawn his/her informed consent form for the participation to the collection and/or VESPER project.

OR

-Patients from St Louis not enrolled in VESPER study:Tumors from patient having expressed opposition against research program after 1 month for the participation to the collection.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Identifying mechanisms of resistance in basal subgroups.	through study completion, an average of 3 years
Identifying molecular subgroups of bladder cancer patients within VESPER and Saint-Louis cohort, who could benefit from neoadjuvant chemotherapy, taking into account the existence of different classification systems.	through study completion, an average of 3 years
Determining which classification(s) has(ve) the best ability to identifying subgroups of tumours sensitive or resistant to neoadjuvant chemotherapy.	through study completion, an average of 3 years

Trial Locations

Locations (1)

DRCI; 🇫🇷 Rouen, France