Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 试验地点
- 2
- 主要终点
- correlation between calcium change and pth change
研究概览
简要总结
Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.
详细描述
Study hypothesis.
Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium.
This may result in higher extraosseous calcification and higher pulse wave velocity
∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •maintenance hemodialysis patients
排除标准
- •dialysis <3 months
- •aortobifemoral graft
- •calcium level predialysis >10.5 mg/dl
结局指标
主要结局
correlation between calcium change and pth change
correlation between calcium change and pth change
correlation between calcium increase and pulse wave velocity
correlation between calcium increase and pulse wave velocity
次要结局
- correlation between calcium increase and vascular calcifications
- correlation between calcium change and bone markers