Arterial Stiffness and Decreased Bone Buffering Capacity in Hemodialysis Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Kidney Disease
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
- Locations
- 1
- Primary Endpoint
- correlation between calcium change and pth change
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Renal patients have an increased risk for cardiovascular complications. There is also increased vascular calcification and bone metabolism is similarly abnormal in patients with chronic kidney disease.
In dialysis patients frequent episodes of hypercalcaemia occur. In a healthy bone structure those episodes of hypercalcemia are buffered by the bone. The absence of bone buffering capacity in dialysis patients can be a mechanism for vascular calcifications.
Detailed Description
Study hypothesis. Patient with a higher ∆ Calcium (Calcium post - Calcium pre) have a diminished bone buffering capacity indicative for adynamic bone disease compared with patients with smaller ∆ Calcium. This may result in higher extraosseous calcification and higher pulse wave velocity ∆ PTH/∆ Calcium may reflect the sensitivity and density of the calcium receptors; this may reflect parathyroid "health"
Investigators
Eligibility Criteria
Inclusion Criteria
- •maintenance hemodialysis patients
Exclusion Criteria
- •dialysis \<3 months
- •aortobifemoral graft
- •calcium level predialysis \>10.5 mg/dl
Outcomes
Primary Outcomes
correlation between calcium change and pth change
correlation between calcium change and pth change
correlation between calcium increase and pulse wave velocity
correlation between calcium increase and pulse wave velocity
Secondary Outcomes
- correlation between calcium increase and vascular calcifications
- correlation between calcium change and bone markers