Vascular Risk Factors and Coronary Calcifications in Chronic Renal Failure Patients: Identification of Specific Factors Linked to Renal Failure Progression

University Hospital, Montpellier1 site in 1 country120 target enrollmentJuly 2007

ConditionsChronic Renal Failure

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Chronic Renal Failure
Sponsor: University Hospital, Montpellier
Enrollment: 120
Locations: 1
Primary Endpoint: description of osteoprotegerin levels according to chronic renal failure progression
Status: Completed
Last Updated: 5 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this study is to appreciate the influence of renal failure progression on vasculopathy (coronary calcifications and left ventricular hypertrophy) and cardiovascular risk factors.

Detailed Description

The aim of this study is to appreciate the relationship between: * extension of coronary calcifications and chronic renal failure progression * extension of coronary calcifications and levels of osteoprotegerin (bone disease marker) * cardiovascular risk factors and coronary calcifications * cardiovascular risk factors and existence of cardiovascular diseases

Registry

clinicaltrials.gov

Start Date

July 2007

End Date

October 2011

Last Updated

5 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Montpellier

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•Patient who has signed the written consent form
•Patient aged \> 18 and \< 90 years
•Chronic renal failure defined by glomerular filtration rate (GFR)
•group 1: GFR \>90 mL/min with urinary biological abnormalities and GFR comprised between 90 and 60 mL/min
•group 2: GFR comprised between 60 and 30 mL/min
•group 3: GFR \<30 mL/min but without dialysis therapy

Exclusion Criteria

•Chronic renal failure patient requiring dialysis therapy

Outcomes

Primary Outcomes

description of osteoprotegerin levels according to chronic renal failure progression

Time Frame: inclusion

Secondary Outcomes

relationship between cardiovascular risk factors and cardiovascular disease(inclusion)
osteoprotegerin description according to calcium score(inclusion)
relationship between cardiovascular risk factors and calcium score(inclusion)
calcium score description according to chronic renal failure progression(inclusion)