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Clinical Trials/NCT00354588
NCT00354588
Completed
Not Applicable

Observational Study on the Prognostic Significance (Renal and Cardiovascular) of Arterial Stiffness and Arterial Wave Reflections in Patients With Mild to Moderate Renal Impairment

Klinikum Wels-Grieskirchen1 site in 1 country115 target enrollmentJanuary 2006
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ConditionsChronic Renal FailureArterial StiffnessArterial Wave Reflections

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Chronic Renal Failure
Sponsor
Klinikum Wels-Grieskirchen
Enrollment
115
Locations
1
Primary Endpoint
renal endpoint
Status
Completed
Last Updated
15 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

  1. Cardiovascular risk is high in patients with renal failure.
  2. Cross-sectional studies have indicated a relationship between arterial stiffness and renal function. However, there are no prospective longitudinal studies in the literature.
  3. In dialysis patients, arterial stiffness as well as wave reflections, predict mortality. However, there are no data on patients with mild-to-moderate renal impairment available.
  4. Therefore, we designed a study to test the hypothesis that: a) measures of arterial stiffness and wave reflections predict the progression of renal impairment in patients with mild-to-moderate renal failure; and b) measures of arterial stiffness and wave reflections predict cardiovascular events in patients with mild-to-moderate renal failure
Registry
clinicaltrials.gov
Start Date
January 2006
End Date
October 2010
Last Updated
15 years ago
Study Type
Observational
Sex
All

Investigators

Sponsor
Klinikum Wels-Grieskirchen

Eligibility Criteria

Inclusion Criteria

  • •chronic renal failure patients (KDOQI III, IV) undergoing regular control visits at our nephrology department
  • •\> 19 years
  • •written informed consent

Exclusion Criteria

  • •atrial fibrillation
  • •valvular heart disease
  • •severely impaired systolic function
  • •no informed consent

Outcomes

Primary Outcomes

renal endpoint

doubling serum creatinine, need for dialysis, renal transplantation

Study Sites (1)

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