Multiparametric Magnetic Resonance Imaging in Patients With Liver Cirrhosis for Evaluation of Myocardial Fibrosis and Inflammation in Cirrhotic Cardiomyopathy

University Hospital, Bonn2 sites in 1 country13 target enrollmentNovember 2, 2018

ConditionsCirrhosis, Liver Cardiomyopathies Portal Hypertension

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Cirrhosis, Liver
Sponsor: University Hospital, Bonn
Enrollment: 13
Locations: 2
Primary Endpoint: Myocardial T1 relaxation time
Status: Completed
Last Updated: 4 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).

Registry

clinicaltrials.gov

Start Date

November 2, 2018

End Date

September 8, 2021

Last Updated

4 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

University Hospital, Bonn

Responsible Party

Principal Investigator

Julian Alexander Luetkens

Prinicipal Investigator, Senior Physician

University Hospital, Bonn

Eligibility Criteria

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Outcomes

Primary Outcomes

Myocardial T1 relaxation time

Time Frame: Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.

T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].

Secondary Outcomes

Myocardial T2 relaxation time(Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.)
Myocardial ECV(Change after 1 year of transjugular intrahepatic portosystemic shunt insertion.)