Myocardial Fibrosis and Inflammation in Liver Cirrhosis
- Conditions
- Cirrhosis, LiverCardiomyopathiesPortal Hypertension
- Registration Number
- NCT05047029
- Lead Sponsor
- University Hospital, Bonn
- Brief Summary
The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Myocardial T1 relaxation time Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].
- Secondary Outcome Measures
Name Time Method Myocardial T2 relaxation time Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].
Myocardial ECV Change after 1 year of transjugular intrahepatic portosystemic shunt insertion. Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].
Trial Locations
- Locations (2)
University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology
🇩🇪Bonn, NRW, Germany
University Hospital Bonn, Medical Clinic and Polyclinic I
🇩🇪Bonn, NRW, Germany
University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology🇩🇪Bonn, NRW, Germany