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Myocardial Fibrosis and Inflammation in Liver Cirrhosis

Completed
Conditions
Cirrhosis, Liver
Cardiomyopathies
Portal Hypertension
Registration Number
NCT05047029
Lead Sponsor
University Hospital, Bonn
Brief Summary

The aim of this clinical prospective study is to assess structural and functional myocardial changes in patients with liver cirrhosis after implantation of transjugular intrahepatic portosystemic shunt (TIPS).

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
13
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Myocardial T1 relaxation timeChange after 1 year of transjugular intrahepatic portosystemic shunt insertion.

T1 relaxation times will be obtained to asses acute myocardial injury and fibrosis. T1 maps will be analyzed using a segmental approach by region of interest analysis. T1 relaxation times are given in \[ms\].

Secondary Outcome Measures
NameTimeMethod
Myocardial T2 relaxation timeChange after 1 year of transjugular intrahepatic portosystemic shunt insertion.

T2 relaxation times will be obtained to asses myocardial edema. T2 maps will be analyzed using a segmental approach by region of interest analysis. T2 relaxation times are given in \[ms\].

Myocardial ECVChange after 1 year of transjugular intrahepatic portosystemic shunt insertion.

Myocardial extracellular volume will be obtained to asses extracellular space/myocardial fibrosis. ECV values will be calculated using a segmental approach by region of interest analysis of native and contrast-enhanced T1 relaxation maps. ECV values are given in \[%\].

Trial Locations

Locations (2)

University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology

🇩🇪

Bonn, NRW, Germany

University Hospital Bonn, Medical Clinic and Polyclinic I

🇩🇪

Bonn, NRW, Germany

University Hospital Bonn, Clinic for Diagnostic and Interventional Radiology
🇩🇪Bonn, NRW, Germany

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