Magnetic Resonance Imaging in the Diagnosis of Pulmonary Hypertension
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 240
- 试验地点
- 1
- 主要终点
- right ventricular function
研究概览
简要总结
The aim of the present study is to identify changes in the cardiovascular system in patients with pulmonary hypertension (PH) by magnetic resonance imaging (MRI). MRI is accepted as golden standard method for the evaluation of left and right ventricular morphology and function.
All patients who showed elevated pulmonary pressure in the right heart catheter investigation are assigned to MRI. Parameters derived from MRI are included in the clinical and therapeutic decisions. Well established as well as new MRI parameters are evaluated and compared to the results of right heart catheter. Further age-matched controls without known cardiac or pulmonary disease are investigated by native MRI.
详细描述
Patients with suspected, latent and manifest PH and controls are investigated by MRI according to the following protocol in breathhold or free breathing (depending on the patients' breath-hold abilities). In case of elevated Creatinin values, no contrast agent is applied.
- Planning of cardiac views: Planning of 2-chamber view, short axes view and 4-chamber view.
- Morphological overview: Transversal and coronal Haste images
- Left and right heart functional and valve evaluation: Cine 2-chamber imaging, Multi-slice cine 4-chamber imaging, Cine Left and Right ventricular outflow tract imaging and Multi-slice cine short axes imaging covering the left and right ventricle for evaluation of EDV, ESV, SV, EF, CO and muscle mass.
- Phase Contrast Imaging: Flow measurements in the aorta, the pulmonary artery and the heart.
- Perfusion measurement.
- Late enhancement measurement: Multi-slice short axes view, multi-slice 2-chamber view and multi-slice 4-chamber view.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Controls without history of cardiac or pulmonary diseases
- •Patients with suspected PH
- •Patients with latent PH
- •Patients with manifest PH
排除标准
- •MRI exclusion criteria
结局指标
主要结局
right ventricular function
时间窗: at the MRI investigation
right ventricular end-diastolic volume (EDV), right ventricular end-systolic volume (ESV), right ventricular stroke volume (SV), right ventricular ejection fraction (EF), right ventricular cardiac output (CO), right ventricular muscle mass (RVMM)
次要结局
未报告次要终点
研究者
Olschewski, Horst, Prof. MD
Univ.-Prof. Dr.
Medical University of Graz