Modulation of Working Memory by an Alternating Magnetic Field in Humans
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 102
- 主要终点
- Sternberg task
研究概览
简要总结
Many studies have examined the effects of transcranial alternating current stimulation (tACS) on working memory, showing that low-intensity stimulation can enhance cognitive performance by modulating neuronal activity, particularly in the frontal cortex and the parietal lobule. Specific frequencies, such as the gamma frequency, have demonstrated beneficial effects on memory under high cognitive load. However, tACS has technical limitations, including uncomfortable sensations and uneven diffusion of electrical currents within the brain, which restrict its effectiveness in deeper brain regions.
Transcranial alternating magnetic stimulation (tAMS) is emerging as a potentially more precise and comfortable method. Unlike tACS, tAMS uses magnetic fields that penetrate more deeply into the brain and provide a more homogeneous distribution of induced electrical currents, allowing for more targeted stimulation. This study compares the effects of tACS and tAMS on working memory, with the hypothesis that tAMS will offer additional advantages in terms of comfort and efficacy. Cognitive performance will be assessed using working memory tasks, along with EEG signals to analyze neuronal modulations. The objective is to demonstrate that tAMS more effectively reaches deep brain regions and improves cognitive functions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Written, voluntary, and informed consent to participate in the study
- •Fluent French speaker (task instructions are provided in French)
- •Normal or corrected-to-normal vision using contact lenses only
- •Non inclusion Criteria:
- •Individuals deprived of liberty by law
- •Individuals under legal guardianship or curatorship
- •Pregnant or breastfeeding women
- •Presence of metallic implants in the head, implanted electronic devices, or any other metallic object that cannot be removed for the experiment (e.g. dental fillings)
- •History of neurological or psychiatric disorders according to the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition)
- •History of pathology or chronic disease affecting memory or attention
- •Drug or alcohol consumption within the previous 24 hours
排除标准
- 未提供
研究组 & 干预措施
40 Hz tACS stimulation
干预措施: Electrical stimulation (Other)
60 Hz tACS stimulation
干预措施: Electrical stimulation (Other)
40 Hz tAMS stimulation
干预措施: Magnetic stimulation (Other)
60 Hz tAMS stimulation
干预措施: Magnetic stimulation (Other)
No stimulation
干预措施: No stimulation (Other)
结局指标
主要结局
Sternberg task
时间窗: Baseline (Day 1, before exposure), periprocedural (Day 1, during exposure), and post-intervention (Day 1, immediately after exposure)
During each trial, participants memorize a sequence of eight letters presented sequentially. They are then shown a probe letter displayed in blue and must indicate whether this letter was part of the memorized sequence. Participant performance will be evaluated based on two behavioral measures: accuracy (proportions of correct and incorrect responses) and reaction time in milliseconds.
次要结局
- EEG Power Outcomes(Baseline (Day 1, before exposure), periprocedural (Day 1, during exposure), and post-intervention (Day 1, immediately after exposure))
- EEG Signal Regularity Outcomes (RQA)(Baseline (Day 1, before exposure), periprocedural (Day 1, during exposure), and post-intervention (Day 1, immediately after exposure))
- Neuropsychological data(Baseline (Day 1, before exposure))