Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.

Not Applicable

Completed

• Conditions: Septic Shock

• Registration Number: NCT00197886
• Lead Sponsor: Herlev Hospital

Brief Summary

Norepinephrine is a drug used to increase blood pressure in patients with life-threatening infection. However, norepinephrine may limit the bloodflow to the gut, thereby causing relative lack of oxygen to the cells. This leads to increased formation of lactic acid.

This study examines whether increasing the dose of norepinephrine leads to higher concentrations of lactic acid in the rectum and stomach in patients with life-threatening infection.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-10
• Study First Submitted: 2005-09-14
• Study First Submitted QC: 2005-09-14
• Study First Posted: 2005-09-20
• Study Completion: 2005-12
• Status Verified: 2006-09
• Last Update Submitted: 2006-09-19
• Last Update Posted: 2006-09-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Septic shock
• NE-dose > 0.1 microg/kg/min
• CI > 3.0 l/min/m2

Exclusion Criteria

• Age < 18, unable to obtain informed consent from relatives
• Untreated hypertension
• Pregnancy
• Pathology in the rectum or stomach
• Limitation of therapy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
L-lactate concentration in the rectum and stomach.

Trial Locations

Locations (1)

Dept. of Intensive Care, Herlev University Hospital; 🇩🇰 Herlev, Denmark