Measurement of Noradrenaline Concentrations Using Different Dilution Methods

• Conditions: Arterial Hypertension

• Registration Number: NCT04772599
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Norepinephrine is the vasopressor of choice for the treatment of peri-anesthetic arterial hypotension. The use of this drug at significantly lower concentrations (dilution factor between 40 and 200) than the commercial preparation is increasingly common in the operating room ("baby-noradrenaline").

In addition, dilution errors are potentially serious for the patient (hypertensive peak) The preparation of precise dilutions is an important factor for the safe use of this medically In this study, the investigators wish to compare the dilution method of the protocol with another method of preparation (left to the free choice of the participant).

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-02
• Study Start: 2021-02-21
• Study First Submitted: 2021-02-23
• Study First Submitted QC: 2021-02-23
• Last Update Submitted: 2021-02-23
• Study First Posted: 2021-02-26
• Last Update Posted: 2021-02-26
• Primary Completion: 2021-07-01
• Study Completion: 2021-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measurement of noradrenaline concentrations using different dilution methods	1 hour after the preparation of the noradrenaline solutions	Measurement methods: * High performance liquid chromatography; * Measurement of the concentration of noradrenaline in the biochemical laboratory of the University Hospitals of Strasbourg

Trial Locations

Locations (1)

Strasbourg University Hospitals - Anesthesia-intensive care unit; 🇫🇷 Strasbourg, France