Obsessive-Compulsive Disorder: Formal and Content Modalities, Factors Involved in Loss of Insight, Role of Trauma, and Correlations With Schizophrenia Spectrum Disorders
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Yellbrown (Y-BOCS) Score
研究概览
简要总结
This study aims to better understand Obsessive-Compulsive Disorder (OCD) by examining the types and patterns of OCD symptom presentation. The investigators seek to determine how these symptoms impact overall daily functioning.
The study will also explore factors contributing to loss of insight in individuals with OCD, focusing on the potential roles of trauma, personality traits, and disorder severity. This may assist in identifying subgroups of patients who respond more favorably to treatment.
Additionally, the study will investigate how individuals with OCD and schizophrenia spectrum symptoms respond to combined sensory stimuli (e.g., auditory and tactile). The goal is to determine whether these responses are associated with specific brain processing patterns, trauma history, or characteristics of compulsive behavior. Insights from this research may help clarify why certain individuals develop repetitive behaviors such as checking and rituals.
Participants will be adults aged 18 to 65 diagnosed with OCD or schizophrenia spectrum disorders. Recruitment will occur through psychiatric clinics in Parma. Participation requires signed informed consent.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Diagnosis of Obsessive-Compulsive Disorder (OCD) and/or Schizophrenia Spectrum Disorder according to DSM-5 criteria (APA, 2013), as determined by a structured clinical interview (SCID-5-CV) (First et al., 2016).
- •Age between 18 and 65 years.
- •Participant agreement to take part in the study (informed consent).
排除标准
- •General medical condition that may be related to the psychiatric disorder.
- •Alcohol or substance dependence or abuse.
- •Cognitive impairment (score below 25 on the Mini Mental State Examination).
结局指标
主要结局
Yellbrown (Y-BOCS) Score
时间窗: Baseline (single evaluation session)
Assessment of obsessive-compulsive symptom severity using the Yellow-Brown Obsessive-Compulsive Scale (Y-BOCS). The total score ranges from 0 to 40, with higher scores indicating more severe symptoms. This scale is a clinician-administered questionnaire evaluating obsessions and compulsions
次要结局
- Simultaneity Judgement Task (SJ) Performance(Approximately 15 minutes during the pre-training session)
- Childhood Trauma Questionnaire-Short Form (CTQ-SF) Total Score(Baseline (single evaluation session))
- Simultaneity Judgement Training (SJT) Performance(Approximately 30-45 minutes during the training session)
研究者
Matteo Tonna
Associate Professor of Psychiatry, University of Parma
Azienda Ospedaliero-Universitaria di Parma