Optimal Early Systolic Blood Pressure and Renal Outcome of Sepsis-associated Acute Kidney Injury in Non-critically Ill Patients : A Retrospective Cohort Study

Completed

• Conditions: 1.To investigate the association of early systolic blood pressure (within the first 48 hours) in sepsis without septic shock patients with SA-AKI and renal outcome2.To determine the optimal early blood pressure that associated with the best renal outcome and mortality; Acute kidney injury, Sepsis, Non-critically ill, Blood pressure

• Registration Number: TCTR20240409001
• Lead Sponsor: Faculty of Medicine, Chiang Mai University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2023-12-31
• Study Start: 2024-04-09
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 476

Inclusion Criteria

1. Patient more than 18 years old, admitted in non-ICU ward
2. Meet the criteria of sepsis according to The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3) including suspected or documented infection and an acute increase of greater equal to 2 SOFA points.
3. Meet the criteria of AKI according to KDIGO definition based on serum
Cr measurement
4. Both criteria for sepsis and AKI were presented simultaneously within 48 hours after admission

Exclusion Criteria

1. Critically ill patient defined as septic shock according to Sepsis-3, ICU admission, need for mechanical ventilation at the first 48 hour of admission
2. End stage renal disease or chronic kidney disease stage 5
3. Lack of baseline Cr within 1 year before diagnosis of AKI

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Composite of long-term renal replacement therapy, a decrease of at least 25% in eGFR within 1 year after diagnosis of AKI, and 1-year mortality 1 year hemodialysis status, serum creatinine at 1 year, overall survival

Secondary Outcome Measures

Name	Time	Method
ong term renal replacement therapy 1 year hemodialysis status,Decrease of at least 25% of eGFR within 1 year after diagnosis of AKI 1 year serum creatinine at 1 year,1-year mortality 1 year overall survival,30-day mortality 30 days overall survival,Initiate renal replacement therapy 1 year Hemodialysis status,Recurrent AKI 1 year serum creatinine within 1 year ,Readmission 1 year admission record