NL-OMON50171招募中不适用
The etiology and extent of impaired quality of life, fatigue and cognitive, affective and emotional dysfunction in patients with Cushing*s syndrome ;- Prospective studies using structural and functional magnetic resonance imaging, positron emission tomography, genetic and cerebrospinal fluid analysis - <br> - The etiology of impaired QoL and cognitive dysfunction in patients with CS
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 24
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 64（—）
入选标准
- •Male and female patients with Cushing's syndrome caused by ACTH-producing
- •pituitary adenoma or cortisol producing adrenal adenoma
- •Age between 18 and 65 years
排除标准
- •Cushing's syndrome caused by ectopic ACTH producing tumours
- •Cushing's syndrome caused by adrenocortical carcinoma
- •Pseudo Cushing
- •Subclinical Cushing's syndrome
- •Exogenous CS
- •Previous history of major psychiatric disorder (not related to Cushing's
- •Neurological disorders affecting the central nervous system
- •High alcohol consumption (more than 14 alcohol units per week)
- •Active malignancy or any treatment for malignancy during the last 2 years
- •Heart failure (NYHC II-IV)
- •Severe respiratory insufficiency
- •Severely impaired hepatic function (ALT and/or AST concentrations two times
- •above the upper limit of normal)
- •Severely impaired renal function (s-creatinine >150 µmol/L or GFR <45 ml/min)
- •Pregnancy or breast feeding
- •Any other illness that significantly affects the patients cognitive function
- •according to the investigators opinion
- •Contraindication for MRI (Presence of medical implants, metal in the body,
- •claustrophobia)
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