Rectal Cancer AIMS Academy Clinical Research Network Registry

Brief Summary

Detailed Description

Study parameters Patients with an histological diagnosis of rectal cancer will undergo pre-operative staging as follow: * Chest-Abdominal TC scan with e.v. contrast. * Complete colonoscopy * Pelvic MRI with e.v. contrast with measurements of all the tumours aspects. * Endorectal US examination * Serum level of CEA and CA 19,9 and full nutritional status will be analysed * Complete oncological and pathological medical history examination. * Data from place of birth and places where patients lived will be collected. * Sex and race Charlson Comorbidities Index adjusted for age will be calculated for each patient while Robinson Score will be calculated for aged over 70 patients. Symptoms at presentation (Haemorrhagic framework ,alvo alteration, pain) will be collected. For Locally advance rectal cancer neo adjuvant chemoradiotherapy will be planned. Grey dose received and total dose of chemotherapy administrated together with eventual toxicity and reasons for non completing the therapy will be collected. Patients will be re-staged with pelvic MRI, endorectal US, colonoscopy. Radiological and endoscopic disease response to neo adjuvant treatment criteria will be noted. Intraoperative analysed parameters will include : * time of surgery * blood loss * type of analgesia * type of technique, conversion * level of IMA ligation * if splenic flexure lowered down * type of energy device used * number and type of cartridge used for rectal stapled line * size of circular stapler used for the anastomosis * if loop ileostomy performed Isto-pathological examination will performed according to WHO 2010 guidelines, Quirke score and Dworak grade in patients who will undergo neo adjuvant chemo-radiation therapy will be reported. Mismatch repair proteins will be reported when analysed. Post operative complication will be described according to Clavien Dindo complication scale. Day of discharge and eventual post discharge complication will be evaluated. Application of an ERAS protocol will be added only for at least 80% of ERAS colo-rectal items satisfied. Indication to eventual adjuvant therapy given within a multidisciplinary setting will be noted. Type of therapy, duration of the treatment and a full description of the compliance to the treatment will be described. Oncological follow up will be performed according to National Comprehensive Cancer Network guidelines. Functional follow up will be done yearly with the Low Anterior Resection Syndrome Score.

Primary Outcomes

Secondary Outcomes

• Quality of life Scale (QOLS)(at 5 years from surgery)