Pitch Perception and Memory: Deficits and Training

Not Applicable

Recruiting

• Conditions: Cochlear Implants
• Interventions: Behavioral: Listening tests. Pitch training protocol; Behavioral: visuo-spatial training protocol; Behavioral: EEG/MEG/MRI recordings.

• Registration Number: NCT03707691
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Pitch perception and memory are central in auditory cognition, in particular for sound source segregation and recognition, speech prosody and music processing. Here the investigator assess pitch perception and memory in hearing-impaired listeners wearing cochlear implant(s) and listeners with congenital amusia, both compared with control listeners. Behavioral, EEG, and MEG measures are collected in audio and audio-visual contexts to characterize pitch processing deficits, and test a pitch training program.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-10-12
• Study First Submitted QC: 2018-10-12
• Study First Posted: 2018-10-16
• Study Start: 2019-11-26
• Status Verified: 2024-04
• Last Update Submitted: 2024-04-16
• Last Update Posted: 2024-04-17
• Primary Completion: 2025-10-26
• Study Completion: 2025-10-26

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 960

Inclusion Criteria

For adult participants:

• Aged between 18 and 90
• Absence of neurological and psychiatric disorders
• No major cognitive deficit, ability to understand and apply study instructions
• Motivation to participate efficiently in the study
• Written informed consent to participant in the study
• Affiliated to social security
• Control participants and participants with congenital amusia for Experiment 5: MRI/MEG compatibility

For underage participants:

• Subject aged 5 years and over
• Informed consent of parents or guardians for the participation of the child being studied
• No neurological or psychiatric history
• Without major cognitive impairment and ability to understand and apply setpoint.
• Subject affiliated to a social security scheme
• Motivation to participate effectively in the project

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Exclusion Criteria

For adult participants:

• Age below 18 or above 90
• Pregnant or breast-feeding woman

For underage participants:

• Pregnant or nursing minors

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Participants with Congenital Amusia	Listening tests. Pitch training protocol	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Cochlear implant users	EEG/MEG/MRI recordings.	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Control Participants	Listening tests. Pitch training protocol	-
Control Participants	visuo-spatial training protocol	-
Cochlear implant users	Listening tests. Pitch training protocol	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Participants with Congenital Amusia	visuo-spatial training protocol	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Participants with Congenital Amusia	EEG/MEG/MRI recordings.	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Cochlear implant users	visuo-spatial training protocol	In both arms a pitch training protocol and a visuo-spatial training protocol are applied.
Control Participants	EEG/MEG/MRI recordings.	-

Primary Outcome Measures

Name	Time	Method
percentages of correct responses in listening tests	during procedure
reaction times in listening tests	during procedure
Event-Related Fields	during procedure	MEG measurements
Oscillations	during procedure	MEG measurements

Secondary Outcome Measures

Name	Time	Method
percentages of correct responses	Day 0	Performance in listening tests in audio-visual contexts
Event-Related Fields	Day 0	EEG measurements
reaction times	Day 0	Performance in listening tests in audio-visual contexts
Oscillations	Day 0	EEG measurements

Trial Locations

Locations (1)

Lyon Neuroscience Research Center; 🇫🇷 Bron, France