Circulation in the smallest vessels in neonates suspected of necrotizing enterocolitis.
- Conditions
- ecrotizing enterocolitis (NEC). In Dutch: necrotiserende enterocolitis.
- Registration Number
- NL-OMON23436
- Lead Sponsor
- Erasmus Medical Center
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 180
Inclusion Criteria
1. Group 1: All neonates suspected of NEC or severe feeding intolerance;
2. Group 2: Control patients for group 1, matched for gender and age;
Exclusion Criteria
Severe cardiac and respiratory anomalies.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To determine the microcirculatory profile in infants with persistent feeding intolerance or suspected NEC. We would like to determine whether NEC is associated with a regional decreased microcirculation.
- Secondary Outcome Measures
Name Time Method 1. To determine whether microcirculatory measurements can be used to predict which infants will need surgical intervention for NEC;<br /><br>2. To quantify the mesenteric arterial circulation during laparotomy using SDF and to correlate these values with the ones obtained prior to surgery;<br /><br>3. To determine the correlation between microcirculatory and macrocirculatory measurements (RR);<br /><br>4. To evaluate mesenterial vascular responses by in vitro pharmacology and especially focus on the role of NO and his products;<br /><br>5. To evaluate whether surgical intervention improves microcirculation.