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临床试验/NCT04417608
NCT04417608Unknown不适用

Looking for Minimum Dose to Induce Sympathectomy in Infraclavicular Brachial Plexus Block

Taipei Medical University WanFang Hospital0 个研究点目标入组 66 人开始时间: 2020年6月4日最近更新:
适应症

试验速览

阶段
不适用
入组人数
66
主要终点
Change of diameter of basilic vein and brachial artery

研究概览

简要总结

For patients who undergoing hemodialysis, it is important to have good AV fistula. One third of AV fistula usually fail during early stage. It is helpful to use nerve block to dilate the blood vessels and enhance the prognosis. But 0.2% Ropivacaine usually cause muscle weakness in present studies. The investigators hope to find the lowest concentration to provide sympathectomy without muscle weakness. Because the patients with hemodialysis usually have multiple co-morbidity, thus we choose patients with forearm fracture at the first place. With this result, the investigators can design further study for patients with hemodialysis. The investigators prefer proximal approach because brachial plexus run together in the cosctoclavicular space and show lower incidence of incomplete work.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age between 20-80 y/o, BW: 40-90 kilograms,ASA class I-III,No pre-existing neuropathy,Scheduled for upper limb surgery.

排除标准

  • Pre-existing neuropathy (ex: polyneuropathy)
  • History of allergy to xylocaine、ropivacaine、epinephrine
  • Emergent surgery
  • Coagulopathy
  • Patient who can not express themselves

结局指标

主要结局

Change of diameter of basilic vein and brachial artery

时间窗: Change from baseline diameter(pre-nerve block) at 48hour

Use ultrasound to measure the difference of diameter at different time point.

次要结局

  • Motor block of upper limb(48hour post nerve block)
  • Sensory block of upper limb(24hour post nerve block)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

anchihhsu

Principal Investigator

Taipei Medical University WanFang Hospital

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